|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs7903146-T is associated with a decreased insulin concentration and increased risk of T2D with opposing effects of adjustment for adiposity.
|
29174029 |
2018 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A case-control study was performed in Han Chinese subjects with normal control (n=152) and T2DM (n=227), we genotyped rs7903146 and rs11196218 at TCF7L2, rs13266634 at SLC30A8, rs3811951 at PCSK1 and rs2021785 at PCSK2.
|
21437630 |
2012 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A gene dosage effect of the rare allele of both variants was observed, the heterozygote CT group of rs7903146 having an odds ratio of 1.36 (95% CI 1.2-1.5, p=1.54 x 10(-7)) for type 2 diabetes and the TT homozygote having a greater risk (OR = 2.03, 95% CI 1.7-2.5, p=1.40 x 10(-12)).
|
17429603 |
2007 |
|
rs7903146
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs7903146
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
|
20818381 |
2010 |
|
rs7903146
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
|
rs7903146
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs7903146
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A significant increase of GT/TT genotypes of the rs12255372 single-nucleotide polymorphism (SNP) and CT/TT genotypes of the rs7903146 SNP was observed in low GADA titre and Type 2 diabetes compared with high GADA titre, Type 1 diabetes and controls (P < or = 0.04 for both comparisons).
|
20546291 |
2010 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A total of 750 individuals, including 322 patients with T2DM and 120 patients with diabetic foot ulcers (DFUs) and 308 controls, were analyzed for rs7903146 variant of the TCF7L2 gene.
|
24214952 |
2013 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
|
17460697 |
2007 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A variant in TCF7L2 associated with type 2 diabetes (the T allele at rs7903146) was associated with diabetes in CF in the family study (p = 0.004) and in the case-control study (p = 0.02; combined p = 0.0002).
|
19585101 |
2009 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146</span>, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005).
|
31676834 |
2019 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Adropin peptide may have roles in T2DM pathogenesis due to several roles in glucose tolerance, decrement of insulin resistance, lipid metabolism and energy homoeostasis.<b>Aim:</b> To evaluate the serum level of adropin in T2DM patients and comparing with healthy individuals as well as assessing frequency of rs7903146 genotypes/alleles in patients and control groups.<b>Methods:</b> We analysed the frequency of rs7903146 genotypes/alleles in 93 patients with T2DM disease and 53 healthy individuals by the method of polymerase chain reaction-restriction fragment length polymorphism analysis.
|
31818149 |
2019 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After adjusting for age, gender, drinking, smoking and body mass index (BMI), the association of <i>TCF7L2</i> rs7903146C>T and rs290481 T>C polymorphisms with T2DM was determined.
|
29100364 |
2017 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After adjustment for confounding variables, we observed a negative impact of the type 2 diabetes allele of SNP rs7903146 on change in BMI (P = 0.0034) and on changes in nonvisceral (P = 0.0032) and visceral fat (P = 0.0165) during lifestyle intervention.
|
20028944 |
2010 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After adjustment for potential contributory factors, nominally significant associations were seen between TT genotype and the recessive model of TCF7L2 rs7903146 and increased risk of T2DM [hazard ratio (HR)=4.068, 95% confidence interval (CI): 1.270-13.026; HR=4.051, 95% CI: 1.268-12.946, respectively].
|
27998387 |
2016 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although previous studies showed that the association between the SNP rs7903146 in the TCF7L2 gene and T2D was controversial within the Han Chinese population, we have confirmed the significant association between the SNP rs7903146 in the TCF7L2 gene and T2D in both this study and the meta-analysis in the population.
|
20550665 |
2010 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among AA youth, each copy of the T allele (rs7903146) was associated with a 1.97-fold (1.37, 2.82) increased odds for type 2 diabetes (p < 0.0001), after adjustment for age, sex, BMI and African ancestry.
|
21109996 |
2011 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association between transcription factor 7-like 2 rs7903146 polymorphism and diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis.
|
26316572 |
2015 |