Gene: HNF1B ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10908278
rs10908278
HNF1B
T 0.700 GeneticVariation GWASCAT Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. 26818947

2016
dbSNP: rs11263763
rs11263763
HNF1B
0.700 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012
dbSNP: rs11651052
rs11651052
HNF1B
0.800 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012
dbSNP: rs11651052
rs11651052
HNF1B
A 0.800 GeneticVariation GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926

2019
dbSNP: rs11651052
rs11651052
HNF1B
A 0.800 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012
dbSNP: rs11651755
rs11651755
HNF1B
0.800 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012
dbSNP: rs11651755
rs11651755
HNF1B
C 0.800 GeneticVariation GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458

2018
dbSNP: rs121918672
rs121918672
HNF1B
0.010 GeneticVariation BEFREE The subject with the R276X mutation had MODY5 misdiagnosed as common type 2 diabetes. 12161522

2002
dbSNP: rs121918673
rs121918673
HNF1B
C 0.810 CausalMutation CLINVAR

dbSNP: rs121918673
rs121918673
HNF1B
0.810 GeneticVariation UNIPROT The S465R mutation was found in 0.5% of our patients with common type 2 diabetes and thus may be a rare genetic risk factor contributing to the development of type 2 diabetes rather than MODY5. 12161522

2002
dbSNP: rs121918673
rs121918673
HNF1B
0.810 GeneticVariation UNIPROT Recommendations from the EGAPP Working Group: does genomic profiling to assess type 2 diabetes risk improve health outcomes? 23492873

2013
dbSNP: rs121918673
rs121918673
HNF1B
0.810 GeneticVariation BEFREE The S465R mutation was found in 0.5% of our patients with common type 2 diabetes and thus may be a rare genetic risk factor contributing to the development of type 2 diabetes rather than MODY5. 12161522

2002
dbSNP: rs121918673
rs121918673
HNF1B
0.810 GeneticVariation UNIPROT Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. 22962670

2012
dbSNP: rs2229295
rs2229295
HNF1B ; LOC105371755
0.010 GeneticVariation BEFREE One 3'UTR SNP (rs2229295) in the HNF1B gene was significantly associated with T2DM, and the frequency of an A allele (rs2229295) in T2DM patients was decreased compared with that in controls. 26329304

2015
dbSNP: rs3744763
rs3744763
HNF1B
0.700 GeneticVariation GWASDB Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. 21874001

2011
dbSNP: rs4430796
rs4430796
HNF1B
G 0.870 GeneticVariation GWASCAT A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. 22961080

2013
dbSNP: rs4430796
rs4430796
HNF1B
0.870 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160

2012
dbSNP: rs4430796
rs4430796
HNF1B
0.870 GeneticVariation BEFREE We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes. 21499250

2011
dbSNP: rs4430796
rs4430796
HNF1B
0.870 GeneticVariation BEFREE Besides, the haplotype-based analysis demonstrated that AGT in block rs752010-rs4430796-rs7501939 was associated with about 30% increase in T2D risk (OR 1.31, 95% CI 1.09-1.57, P = 0.01). 23300827

2012
dbSNP: rs4430796
rs4430796
HNF1B
A 0.870 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590

2017
dbSNP: rs4430796
rs4430796
HNF1B
G 0.870 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014
dbSNP: rs4430796
rs4430796
HNF1B
0.870 GeneticVariation BEFREE Where type 2 diabetes was the outcome, only one statistically significant interaction effect was observed, and this was for the HNF1B rs4430796 variant (P(interaction) = 0.0004). 19324937

2009
dbSNP: rs4430796
rs4430796
HNF1B
G 0.870 GeneticVariation GWASDB A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. 22961080

2013
dbSNP: rs4430796
rs4430796
HNF1B
0.870 GeneticVariation BEFREE Nominal interactions were observed for sleep duration and PPARG rs1801282, CRY2 rs7943320 and HNF1B rs4430796 in influencing risk of type 2 diabetes (p < 0.05). 24280871

2014
dbSNP: rs4430796
rs4430796
HNF1B
0.870 GeneticVariation BEFREE The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM. 31299695

2019