|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the association of Trp64Arg with type 2 diabetes was examined in a meta-analysis.
|
18249022 |
2008 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is unlikely to be a major genetic predisposer to NIDDM or insulin resistance syndrome in subjects from eastern Finland.
|
9250462 |
1997 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The beta(3)-adrenergic receptor gene (BAR-3) allelic variant (Trp64Arg and Arg64Arg) is correlated with obesity or non-insulin-dependent diabetes mellitus.
|
12943691 |
2003 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg allele of the beta 3-adrenergic receptor is associated with abdominal obesity and resistance to insulin and may contribute to the early onset of NIDDM:
|
7609751 |
1995 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg mutation is not a major determinant of Type 2 diabetes and its microangiopathic complications.
|
10197086 |
1998 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a missense mutation replacing tryptophan with arginine at codon 64 of the beta 3-adrenergic receptor gene was shown to be associated with insulin resistance in nondiabetic subjects and to an earlier onset of NIDDM in Pima Indians.
|
8690160 |
1996 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.
|
18335327 |
2008 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus.
|
10981554 |
2000 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population.
|
22391941 |
2012 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism in the beta3AR gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes; little is known about its possible association with cancer.
|
15743038 |
2004 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, heterozygosity for the Trp64Arg variant is unlikely to increase the risk of obesity, insulin resistance or type 2 diabetes.
|
16634992 |
2006 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men.
|
11699048 |
2001 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg beta3AR variant is associated in some, but not all, studies with an earlier onset of Type 2 diabetes mellitus and features of the insulin resistance syndrome.
|
10441039 |
1999 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
UCP1 -3826A/G and ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) Caucasian-Brazilian patients.
|
24138564 |
2014 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta3-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.
|
17852419 |
2007 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.
|
11522702 |
2001 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.
|
9709965 |
1998 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03).
|
21992420 |
2011 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The β3-adrenoceptor (ADRB3) gene Trp64Arg polymorphism has been shown to be associated with obesity as well as type 2 diabetes and cardiovascular disease.
|
22609474 |
2012 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients.
|
20536507 |
2010 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the Trp64Arg mutation is not a major determinant of metabolic disorders (type 2 diabetes, obesity) and chronic complications of type 2 diabetes in a Dutch population.
|
11213599 |
2001 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of β3-adrenergic receptor rs4994 polymorphisms with the risk of type 2 diabetes: A systematic review and meta-analysis.
|
28521197 |
2017 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the TRP64ARG beta 3AR mutation or any other mutation in the beta 3AR gene is not a major contributor to genetic susceptibility to NIDDM and obesity likely in Nauruans.
|
8923875 |
1996 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Non-diabetic subjects heterozygous for the mutation were more obese and Trp/Arg diabetics had a slightly younger age of onset of NIDDM (47 vs 51 years, respectively), but there were no significant differences in mutation frequency between the two groups.Metabolic parameters (e.g. fasting lipids and glycaemic control) were similar among diabetic subjects with and without the Trp64Arg mutation.3.
|
9315379 |
1997 |
|
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes.
|
11380082 |
2001 |