rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The current study demonstrated a modest but significant effect of SLC30A8 (rs13266634) polymorphisms on T2D predisposition.
|
31823921 |
2019 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For the rs9939609 variant (FTO), the dominant model AA/(AT+TT) revealed significant association with T2D [odds ratio (OR)=2.03, P=0.021], but was non-significant post correction for multiple testing (P=0.002).
|
31823921 |
2019 |
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interestingly, the highest level of adropin was detected in T2DMpatients with rs7903146T/T genotype.<b>Conclusion:</b> Our analysis showed higher level of adropin in T2DM patients and increased risk of T2DM with rs7903146T/T and rs7903146C/T genotypes.
|
31818149 |
2019 |
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interestingly, the highest level of adropin was detected in T2DMpatients with rs7903146T/T genotype.<b>Conclusion:</b> Our analysis showed higher level of adropin in T2DM patients and increased risk of T2DM with rs7903146T/T and rs7903146C/T genotypes.
|
31818149 |
2019 |
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Adropin peptide may have roles in T2DM pathogenesis due to several roles in glucose tolerance, decrement of insulin resistance, lipid metabolism and energy homoeostasis.<b>Aim:</b> To evaluate the serum level of adropin in T2DM patients and comparing with healthy individuals as well as assessing frequency of rs7903146 genotypes/alleles in patients and control groups.<b>Methods:</b> We analysed the frequency of rs7903146 genotypes/alleles in 93 patients with T2DM disease and 53 healthy individuals by the method of polymerase chain reaction-restriction fragment length polymorphism analysis.
|
31818149 |
2019 |
rs3758391
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The polymorphisms rs3758391 and rs1800470 located in SIRT1 and TGF-β1 have been associated with type 2 diabetes in different populations but its functional effect is not clear.
|
31799723 |
2020 |
rs1800470
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The polymorphisms rs3758391 and rs1800470 located in SIRT1 and TGF-β1 have been associated with type 2 diabetes in different populations but its functional effect is not clear.
|
31799723 |
2020 |
rs10830963
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These data suggest that the <i>MTNR1B</i> rs10830963 and rs1387153 polymorphisms are associated with repaglinide monotherapy efficacy in Chinese patients with T2DM.
|
31787898 |
2019 |
rs1387153
|
|
|
0.880 |
GeneticVariation |
BEFREE |
These data suggest that the <i>MTNR1B</i> rs10830963 and rs1387153 polymorphisms are associated with repaglinide monotherapy efficacy in Chinese patients with T2DM.
|
31787898 |
2019 |
rs7873784
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We hypothesize that additional functional PU.1 site may increase TLR4 expression in individuals carrying minor C variant of rs7873784 and modulate the development of certain pathologies, such as rheumatoid arthritis and type-2 diabetes mellitus.
|
31785408 |
2020 |
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results provide evidence that genetic variation in <i>TCF7L2</i> rs7903146 could increase risk for peripheral arterial disease in patients exhibiting long-standing type 2 diabetes.
|
31775533 |
2020 |
rs11254375
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
rs1801224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
rs4366393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
rs6602175
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
rs7071576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
|
31759989 |
2020 |
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
|
31759989 |
2020 |
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
|
31759989 |
2020 |
rs7896005
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
|
31759989 |
2020 |
rs3781907
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
|
31759989 |
2020 |
rs10830963
|
|
|
0.900 |
GeneticVariation |
BEFREE |
While marginal evidence of interaction between self-reported morningness-eveningness preference and rs10830963 in risk of type 2 diabetes was seen, this interaction did not persist when analysis was expanded to include all participants regardless of employment status and when accelerometer-derived sleep midpoint was used as an objective measure of morningness-eveningness preference.
|
31757795 |
2020 |
rs1501299
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, we concluded on the basis of observed results that the ADIPOQ gene polymorphisms rs822396 and rs1501299 plays an important role in the development of type 2 diabetes in North Indian Punjabi population.
|
31755094 |
2019 |
rs822396
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Thus, we concluded on the basis of observed results that the ADIPOQ gene polymorphisms rs822396 and rs1501299 plays an important role in the development of type 2 diabetes in North Indian Punjabi population.
|
31755094 |
2019 |
rs352165
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The meta-analysis between BD and T2D identified six significant SNPs, three of which were located in ALAS1 (best SNP: rs352165, p = 3.4E-08).
|
31754094 |
2019 |