|
rs1111875
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs1111875
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs1111875
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs1111875
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant.
|
17827400 |
2007 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNPs rs5015480 [odds ratio (OR) = 1.46 (95% CI 1.20-1.77), p = 2.0 x 10(-4)], rs7923837 [OR = 1.40 (95% CI 1.17-1.68), p = 2.0 x 10(-4)] and rs1111875 [OR = 1.30 (95% CI 1.11-1.52), p = 0.0013] in HHEX were significantly associated with type 2 diabetes with the same direction as previously reported.
|
17928989 |
2007 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The G allele of rs1111875 was also associated with type 2 diabetes (odds ratio 1.42, 95% CI 1.13-1.78; P = 0.0024).
|
17971426 |
2008 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For both polymorphisms, the risk for T2D was significantly increased in carriers of the major alleles (rs7923837: odds ratio (OR): 1.57, 95% confidence interval (CI): 1.08-2.27, P=0.017 and rs1111875: OR: 1.68, 95% CI: 1.19-2.35, P=0.003).
|
18231124 |
2008 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A total of 15 SNPs were genotyped.Eight SNPs in five loci were found to be associated with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI) 1.05-1.27); P = 4.5 x 10(-3)] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14-1.40); P = 1.4 x 10(-5)] and rs7923837 [OR = 1.27 (95% CI 1.13-1.43); P = 1.0 x 10(-4)] in HHEX; rs10811661 [OR = 1.27 (95% CI 1.15-1.40); P = 1.9 x 10(-6)] in CDKN2B; rs4402960 [OR = 1.23 (95% CI 1.11-1.36); P = 8.1 x 10(-5)] and rs1470579 [OR = 1.18 (95% CI 1.07-1.31); P = 8.3 x 10(-4)] in IGF2BP2; and rs7754840 [OR = 1.28 (95% CI 1.17-1.41); P = 4.5 x 10(-7)] and rs7756992 [OR = 1.27 (95% CI 1.15-1.40); P = 9.8 x 10(-7)] in CDKAL1.
|
18477659 |
2008 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The G allele of rs1111875 (OR = 1.43, 95% CI = 1.18-1.72, p = 1.8 x 10(-4)) in HHEX), the T allele of rs10811661 (OR = 1.47, 95% CI = 1.23-1.75, p = 2.1 x 10(-5)) in CDKN2A/B) and the C allele of rs2237892 (OR = 1.31, 95% CI = 1.10-1.56, p = 0.003) in KCNQ1 showed significant associations with T2DM.
|
18991055 |
2008 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition to these polymorphisms, meta-analysis confirmed the association of type 2 diabetes susceptibility with KCNJ11 rs5219, TCF7L2 rs7903146, and HHEX rs1111875.
|
19033397 |
2009 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the present study, we aimed to validate the type 2 diabetes (T2DM) susceptibility alleles identified in the first genome-wide association study in the hematopoietically expressed homeobox protein (HHEX) gene region (rs1111875 and rs7923837).
|
19117022 |
2009 |
|
rs1111875
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs1111875
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The HHEX-IDE rs1111875 variant showed no significant association among Danes (p = 0.09); however, in a meta-analysis (n = 25,164) this type 2 diabetes risk allele was associated with lower birthweight (beta = -16 g [95% CI -24, -8], p = 8 x 10(-5)).
|
20490451 |
2010 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied.
|
20550665 |
2010 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, the meta-analysis (7207 cases and 8260 controls) also showed that HHEX rs1111875 did have effects on type 2 diabetes in Chinese population (OR=1.15(1.10-1.21); P=1.93 × 10(-8)).
|
20927120 |
2010 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrated that the C allele of rs1111875 of HHEX is a risk factor associated with increased T2D susceptibility, but these associations vary in different ethnic populations.
|
21056935 |
2011 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrated that the risk allele of HHEX polymorphisms (rs1111875 and rs7923837) is a risk factor for developing T2D.
|
21059810 |
2011 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A cumulative effect of rs7923837 and rs1111875 was observed with individuals carrying 1, 2, and 3 or 4 risk alleles having a 1.27, 1.44, and 1.73-fold increased risk, respectively, for type 2 diabetes (P for trend = 4.1E-10).
|
22506066 |
2012 |
|
rs1111875
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Seven SNPs in six genes known to increase the risk of T2DM in Caucasians were genotyped by means of TaqMan assays in 235 kidney transplant patients medicated with tacrolimus: rs4402960 and rs1470579 in IGF2BP2; rs1111875 in HHEX; rs10811661 upstream of CDKN2A/B; rs13266634 in SLC30A8; rs1801282 in PPARG; rs5215 in KCNJ11.
|
22569928 |
2012 |