|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
|
22961080 |
2013 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
|
22961080 |
2013 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
|
20818381 |
2010 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1).
|
22923468 |
2012 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
COL8A1 rs792837 (P=2.9 × 10(-9)), KCNQ1 rs2237892 (P=1.8 × 10(-18)) and rs2237895 (P=0.002), ALX4 rs729287 (Pc=7.5 × 10(-5)), and HNF1 rs4430796 (P=0.003) were significantly associated with T2DM, with similar effect sizes to those of Europeans.
|
24145053 |
2013 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Following repaglinide treatment, those T2DM patients with the rs2237892 T allele and rs2237895 C allele were more likely to have a positive response to repaglinide in terms of PPG levels (P < 0.05) than T2DM patients with the rs2237892 CC and rs2237895 AA genotypes.
|
22414228 |
2012 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms (SNPs) (rs2237892, rs2237895, rs2237897, and rs2283228) in KCNQ1 are reported to be associated with type 2 diabetes mellitus (T2DM), possibly caused by a reduction in insulin secretion and higher fasting glucose, but the results are inconsistent.
|
20701788 |
2010 |
|
rs2237892
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
23945395 |
2014 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
23945395 |
2014 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Haploview analysis showed that the ACC (rs151290, rs2237892 and rs2237895) haplotype is the most significant risk allele combination for CVD, while CCA is the most significant risk haplotype for co-morbidity with T2D.
|
28863213 |
2019 |
|
rs2237892
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index.
|
20509872 |
2010 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNQ1 rs2237892 C→T gene polymorphism and type 2 diabetes mellitus in the Asian population: a meta-analysis of 15,736 patients.
|
24373634 |
2014 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
|
22158537 |
2011 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Mild association of rs2237892 genotypes with T2DM was seen (P=0.014), highlighted by the significant association of the C/T genotype with increased T2DM risk (OR, 2.11; 95%CI, 1.25-3.53), after adjusting for BMI, gender, systolic and diastolic blood pressure, and serum lipid profile.
|
23107108 |
2012 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Notably, the associations with type 2 diabetes were markedly attenuated after adjusting for HOMA-B (OR(rs2237892): 1.33 [1.05-1.68], P = 0.018; OR(rs2237895): 1.24 [1.00-1.54], P = 0.0524; OR(rs2237897): 1.22[0.98-1.53], P = 0.09).
|
19556355 |
2009 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, significantly elevated T2D risk was associated with rs2237892, rs2237895, rs2237897, rs2283228, and rs231362 risk allele when all studies were pooled into the meta-analysis.
|
23271129 |
2013 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs5215, rs10811661, and rs2237892 were in significant association with T2DM, and hazard ratios per risk allele score increase were 1.11 (95% confidence intervals: 1.06-1.17), 1.09 (1.01-1.05), 1.04 (1.02-1.07) with GPS-3, GPS-18, GPS-36, respectively.
|
26240488 |
2015 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D risk at P ≤ 0.05, including rs6769511 (IGF2BP2), 2 SNPs in the WFS1 gene (rs4689388 and rs1801214), rs7903146 (TCF7L2), and 3 SNPs in the KCNQ1 gene (rs231362, rs2237892, and rs2237897).
|
23144361 |
2012 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNPs rs2237897, rs2237892, and rs2283228 were significantly associated with type 2 diabetes (odds ratio [OR] 1.48, P = 3 x 10(-4); OR 1.38, P = 0.002; OR 1.31, P = 0.012, respectively).
|
19252135 |
2009 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892.
|
18711367 |
2008 |