|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
|
22961080 |
2013 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The main anthropometric and biochemical parameters did not correlate with the rs2237892 or rs2237895 SNPs in the T2DM group (P > 0.05).
|
27323013 |
2016 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
23945395 |
2014 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNQ1 rs2237892 C→T gene polymorphism and type 2 diabetes mellitus in the Asian population: a meta-analysis of 15,736 patients.
|
24373634 |
2014 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The G allele of rs1111875 (OR = 1.43, 95% CI = 1.18-1.72, p = 1.8 x 10(-4)) in HHEX), the T allele of rs10811661 (OR = 1.47, 95% CI = 1.23-1.75, p = 2.1 x 10(-5)) in CDKN2A/B) and the C allele of rs2237892 (OR = 1.31, 95% CI = 1.10-1.56, p = 0.003) in KCNQ1 showed significant associations with T2DM.
|
18991055 |
2008 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
|
22158537 |
2011 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, significantly elevated T2D risk was associated with rs2237892, rs2237895, rs2237897, rs2283228, and rs231362 risk allele when all studies were pooled into the meta-analysis.
|
23271129 |
2013 |
|
rs2237892
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
COL8A1 rs792837 (P=2.9 × 10(-9)), KCNQ1 rs2237892 (P=1.8 × 10(-18)) and rs2237895 (P=0.002), ALX4 rs729287 (Pc=7.5 × 10(-5)), and HNF1 rs4430796 (P=0.003) were significantly associated with T2DM, with similar effect sizes to those of Europeans.
|
24145053 |
2013 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1).
|
22923468 |
2012 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The haplotype TCA containing the allele of rs2237892 (T), rs2283228 (C) and rs2237895 (A) was highly protective against T2D (Second model; OR = 0.17, P = 3.7 × 10(-11)).
|
22016621 |
2011 |
|
rs2237892
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index.
|
20509872 |
2010 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNPs rs2237897, rs2237892, and rs2283228 were significantly associated with type 2 diabetes (odds ratio [OR] 1.48, P = 3 x 10(-4); OR 1.38, P = 0.002; OR 1.31, P = 0.012, respectively).
|
19252135 |
2009 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892.
|
18711367 |
2008 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The C allele of rs2237892 variant contributed to susceptibility to T2DM (odds ratio [OR], 1.45; 95% confidence interval [CI], 1.20-1.75).
|
26678516 |
2015 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of the present pilot study suggest for the first time that the KCNQ1 rs2237892 may constitute a shared genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.
|
29520783 |
2018 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35.
|
21103332 |
2010 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The C risk allele in rs2237892 and rs3756555 conferred significantly increased susceptibility to T2D (p=0.001, p=0.003, respectively).
|
20512086 |
2010 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the rs2237892 and rs2237895 polymorphisms in KCNQ1 are associated with elevated type 2 diabetes susceptibility.
|
23133642 |
2012 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We aimed to evaluate the effect of four common variants (rs2237892, rs2283228, rs2237895, and rs2237897) in KCNQ1 on susceptibility of type 2 diabetes (T2D) by performing a case-control study as well as a comprehensive meta-analysis.
|
23786590 |
2013 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892.
|
18711367 |
2008 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
|
22961080 |
2013 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
23945395 |
2014 |