Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1036483919
rs1036483919
GCK
0.020 GeneticVariation BEFREE Early-onset type 2 diabetes mellitus is associated to HNF4A T130I polymorphism in families of central Spain. 25361053

2014

dbSNP: rs1036483919
rs1036483919
GCK
0.020 GeneticVariation BEFREE Mutation p.T130I was associated with both early-onset and late-onset diabetes and caused downregulated HNF4A expression, whereas HNF1A polymorphisms p.I27L and p.S487N were associated with the age of diagnosis of diabetes. 26981542

2016

dbSNP: rs1799884
rs1799884
GCK
0.830 GeneticVariation BEFREE Overall, the pooled results indicated that GCK (rs1799884), GCKR (rs780094) and MTNR1B (rs10830963) were significantly associated with T2DM susceptibility (OR, 1.04; 95%CI, 1.01-1.08; OR, 1.08; 95%CI, 1.05-1.12 and OR, 1.05; 95%CI, 1.02-1.08, respectively). 23840762

2013

dbSNP: rs1799884
rs1799884
GCK
0.830 GeneticVariation BEFREE The GCK rs1799884 A allele was significantly associated with decreased HOMA-B (p([add]) = 0.0005), but not with type 2 diabetes or IFG. 19241058

2009

dbSNP: rs587780346
rs587780346
0.010 GeneticVariation BEFREE The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent. 21978167

2012

dbSNP: rs730497
rs730497
0.010 GeneticVariation BEFREE The most significant association was observed between ESRD age of diagnosis and SNP rs730497, located in intron 1 of the GCK1 gene (recessive T2D age-adjusted P = 0.0006). 20144192

2010

dbSNP: rs1799884
rs1799884
GCK
0.830 GeneticVariation BEFREE The SNP rs1799884 in the GCK promoter was associated with elevated fasting plasma glucose (fPG) concentrations that remained unchanged during the follow-up period (P = 0.4; SE 0.004 [-0.003-0.007]) but did not predict future type 2 diabetes (HR 0.9 [0.8-1.0], P = 0.1). 18332101

2008

dbSNP: rs4607517
rs4607517
GCK
0.020 GeneticVariation BEFREE These seven tag SNPs and rs4607517, a type 2 diabetes variant established in other studies, were analysed in 415 full-heritage non-diabetic Pima Indians characterised for metabolic traits, and 7,667 American Indians who had data on type 2 diabetes and BMI. 24728127

2014

dbSNP: rs4607517
rs4607517
GCK
0.020 GeneticVariation BEFREE We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1). rs340874 (PROX1) and rs174550 (FADS1) were significantly associated with T2D (P=0.0078, OR: 1.12; and P=0.0071, OR: 1.12, respectively). 22992776

2012