rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A total of 236 patients with type 2 diabetes (age: 60.0 ± 10.3 years; diabetes duration: 12.7 ± 8.2 years; 53.4% women) were genotyped for the FTO rs7204609 and rs9939609 polymorphisms (ABI PRISM 7000 Real-Time PCR System).
|
21741858 |
2012 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ADORA/rs903361, CADM2/rs13078807, GNPDA2/rs10938397, VEGFA/rs6905288 and FTO/rs9939609 are associated with an increased risk of pediatric-onset type 2 diabetes in the Mexican population.
|
28401323 |
2017 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2).
|
28738793 |
2017 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association of rs9939609 variant with higher FBG, plasma insulin, and leptin levels indicates that this polymorphism may disturb the metabolism in adult females and predispose them to obesity and type 2 diabetes.
|
24102053 |
2013 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
CONCLUSIONS Polymorphisms in CDKN2A/2B and FTO, but not CDKAL1, may be associated with T2D, and alleles rs8050136 and rs9939609 are likely risk alleles for T2D in this population.
|
26873362 |
2016 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For the rs9939609 variant (FTO), the dominant model AA/(AT+TT) revealed significant association with T2D [odds ratio (OR)=2.03, P=0.021], but was non-significant post correction for multiple testing (P=0.002).
|
31823921 |
2019 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
rs9939609
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
rs9939609
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, no significant association was found between genetics and risk of type 2 diabetes after control of potential confounders (at least for BMI) either for rs9939609 (fixed effect OR=1.05, 95% CI=0.97,1.13) or for rs8050136 polymorphism (fixed effect OR =1.07, 95%CI: 0.99, 1.16).
|
20337217 |
2009 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In studies of 3,856 type 2 diabetic case subjects and 4,861 normal glucose-tolerant control subjects, the minor A-allele of rs9939609 associated with type 2 diabetes (odds ratio 1.13 [95% CI 1.06-1.20], P = 9 x 10(-5)).
|
17942823 |
2008 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the meta-analysis of 42 studies for 11 obesity/BMI-associated loci, we observed a statistically significant association of the FTO rs9939609 polymorphism (66 425 T2D cases/239 689 normoglycaemic subjects; P = 1·00 × 10(-41) ) and six other variants with T2D risk (17 915 T2D cases/27 531 normoglycaemic individuals: n = 40 629-130 001; all P < 0·001 for SH2B1 rs7498665, FAIM2 rs7138803, TMEM18 rs7561317, GNPDA2 rs10938397, BDNF rs925946 and NEGR1 rs2568958).
|
24528214 |
2014 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this case-control study, the associations of rs2241766 T/G of ADIPOQ, rs9289231 T/G of KALRN, and rs9939609 A/T of FTO polymorphisms with genetic susceptibility to CAD in type 2 diabetic (T2D) patients were investigated.
|
27218147 |
2016 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
|
22158537 |
2011 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, the homozygous AA genotype of rs9939609 was associated with a higher risk of type 2 diabetes mellitus (odds ratio = 1.45 [1.05-1.99], P = .02, 283 subjects with and 2601 subjects without type 2 diabetes mellitus), independently of BMI.
|
19375760 |
2009 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
None of the variants including previously reported intron 1 variants (rs1421085, rs8050136, rs9939609 and rs9930506) showed body mass index (BMI)-dependent/independent association with type 2 diabetes.
|
21814223 |
2011 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Omentin V109D and FTO rs9939609 genetic variations may change insulin metabolism and have key roles in developing T2D through insulin resistance.
|
31200723 |
2019 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data suggest that the associations between <i>FTO</i> rs9939609, rs8050136 and T2DM are region-related, and the two single-nucleotide polymorphisms contribute to an increased risk of T2DM.
|
28208657 |
2017 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings indicate that the two variants (rs9939609 and rs8050136) in the FTO gene contribute to obesity and T2D in the Asian populations.
|
20057365 |
2010 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Previous genome-wide association studies for type 2 diabetes susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated (FTO) gene region is associated with body mass index (BMI) in European children and adults.
|
20598163 |
2010 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies have showed that common variant (rs9939609) in fat mass and obesity associated (FTO) gene was significantly associated with type 2 diabetes through an effect on human body mass index/obesity.
|
22311015 |
2012 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent studies identified the rs9939609 A-allele of the FTO (fat mass and obesity associated) gene as being associated with obesity and type 2 diabetes.
|
18984658 |
2009 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults.
|
18335027 |
2008 |
rs9939609
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |