|
rs11254375
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
|
rs13207351
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs6214 was associated with T2D [OR = 1.67 (95% CI 1.39-2.01, p = 4.9E-8)], rs13207351 was associated with NPDR [OR = 1.97 (95% CI 1.28-3.03, p = 9.0E-3)]when compared with DNR, and rs5742632 showed positive association with PDR [OR = 1.66 (95% CI 1.33-2.05, p = 1.0E-4)] compared to DNR.
|
31473834 |
2020 |
|
rs1801224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
|
rs3093077
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the C-allele of rs3093077 was associated with higher CRP level in both early- (p=0.016) and late-onset (p<0.001) T2DM.
|
31471424 |
2020 |
|
rs4366393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
|
rs5742632
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs6214 was associated with T2D [OR = 1.67 (95% CI 1.39-2.01, p = 4.9E-8)], rs13207351 was associated with NPDR [OR = 1.97 (95% CI 1.28-3.03, p = 9.0E-3)]when compared with DNR, and rs5742632 showed positive association with PDR [OR = 1.66 (95% CI 1.33-2.05, p = 1.0E-4)] compared to DNR.
|
31473834 |
2020 |
|
rs6214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs6214 was associated with T2D [OR = 1.67 (95% CI 1.39-2.01, p = 4.9E-8)], rs13207351 was associated with NPDR [OR = 1.97 (95% CI 1.28-3.03, p = 9.0E-3)]when compared with DNR, and rs5742632 showed positive association with PDR [OR = 1.66 (95% CI 1.33-2.05, p = 1.0E-4)] compared to DNR.
|
31473834 |
2020 |
|
rs6602175
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
|
rs7071576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Permutation analysis associated rs11254375_G/T (p<sub>emp</sub> = 0.00049, OR = 1.482), rs6602175_G/T (p<sub>emp</sub> = 0.016, OR = 0.822), rs1801224_G/T (p<sub>emp</sub> = 0.025, OR = 0.830), rs4366393_A/G (p<sub>emp</sub> = 0.028, OR = 0.829) and rs7071576_A/G (p<sub>emp</sub> = 0.04, OR = 1.219) with T2DM.
|
31770575 |
2020 |
|
rs10305420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The consistent large clinical impact of rs10305420 on glycemic response and weight response to exenatide makes the variant a strong candidate biomarker for precision medicine, particularly among overweight patients with Type 2 diabetes.
|
30883264 |
2019 |
|
rs1047883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One of the two significantly associated variants, rs1047883 was newly identified whereas rs2108622 had been previously reported to be associated with T2D-related traits.
|
31652446 |
2019 |
|
rs10498210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IRS1- rs10498210 G/A and CCR5-59029 A/G polymorphisms in patients with type 2 diabetes in Kurdistan.
|
30884193 |
2019 |
|
rs1065489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we have analyzed the c.2808G>T, (p.Glu936Asp) CFH polymorphism, which tags the H3 CFH haplotype associated to low plasma factor H levels and predisposing to atypical hemolytic uremic syndrome, in 1,158 type 2 diabetics prospectively followed in the Bergamo nephrologic complications of type 2 diabetes randomized, controlled clinical trial (BENEDICT) that evaluated the effect of the ACEi trandolapril on new onset microalbuminuria.
|
31428128 |
2019 |
|
rs10968576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five SNPs exhibited associations with pediatric-onset T2D in the combined case-parent trio and case-control analysis: LINGO/rs10968576 (odds ratio [OR] 1.82, P = 0.003), POC5/rs2112347 (OR 1.96, P = 2.4E-5), RPS10-NUDT3/rs206936 (OR 1.40, P = 0.023), GLIS3/rs7034200 (OR 2.34, P = 1.2E-6), and VEGFA/rs6905288 (OR 1.58, P = 0.015).
|
30652413 |
2019 |
|
rs11077
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Methods:</b> We conducted a case-control study in genotyping of five polymorphic loci, including <i>RAN</i> rs14035, <i>XPO5</i> rs11077, <i>DICER1</i> rs13078, <i>DICER1</i> rs3742330, and <i>TARBP2</i> rs784567, in miRNA processing genes to explore the risk factors for T2DM and diabetic vascular complications.
|
31354628 |
2019 |
|
rs11255372
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Prior studies indicated that some of transcription factor 7-like 2 (TCF7L2) gene variants such as rs7903146, rs12255372 and rs11255372 are constantly associated with Type 2 diabetes mellitus (T2DM) in various populations and ethnic groups.
|
30776466 |
2019 |
|
rs113754532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the rare p.I28V variant associate with reduced level of fasting plasma glucose and may be protective against type 2 diabetes.
|
31415576 |
2019 |
|
rs11556218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association strength between <i>IL-16</i> gene polymorphism and T2DM risk.<b>Results:</b> The TG genotype and G allele frequencies of rs11556218 increased remarkably in the case group than that in controls (45.86 vs 33.86%; 29.70 vs 20.87%), and the differences reached a significant level (<i>P</i><0.05).
|
31375554 |
2019 |
|
rs1176744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs1176744 in HTR3B was associated with type 2 diabetes.
|
31152805 |
2019 |
|
rs12050217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion</b>: For the first time, we showed that <i>BDKRB1</i> rs12050217 G allele is associated with protection for the advanced stage of DR in T2DM patients; however, further studies are needed to confirm this finding.
|
31017477 |
2019 |
|
rs12050217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results</b>: The genotype frequencies of the <i>BDKRB1</i> rs12050217A/G polymorphism are in Hardy-Weinberg equilibrium and did not differ between T2DM patients and non-diabetic subjects (<i>P</i> > 0.05).
|
31017477 |
2019 |
|
rs12513649
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in CREBRF (rs12513649 and rs373863828) have been strongly associated with increased BMI and decreased risk of type 2 diabetes in Polynesian populations; the A allele at rs373863828 is common in Polynesians but rare in most other global populations.
|
31280340 |
2019 |
|
rs13078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One is a three-factor [<i>DICER1</i> rs13078, body mass index (BMI), and triglyceride (TG)] interaction model for T2DM (OR: 5.93; 95%CI: 1.25-28.26; <i>P</i> = 0.025).
|
31354628 |
2019 |
|
rs13220810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS None of the 4 FOXO3 variants, rs13217795, rs2764264, rs2802292, and rs13220810, were associated with the risk of type 2 diabetes compared to controls.
|
31009445 |
2019 |
|
rs14035
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Another three-factor [<i>RAN</i> rs14035, hypertension (HP), and duration of T2DM (DOD)] interaction model was found for macrovascular complications of T2DM (<i>OR</i> = 41.60, 95%CI = 11.75-147.35, <i>P</i> < 0.001).
|
31354628 |
2019 |