Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE The <i>KCNJ11</i> SNP rs5210 was associated with T2DM, the <i>TCF7L2</i> SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the <i>TCF7L2</i> SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the <i>HNF4A</i> SNP rs1885088 was associated with LDL levels (P<0.05). 28352326

2017

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE The heterozygous genotypes CT, GT and TC of the rs7903146 (T is risk for Type 2 diabetes), rs12255372 (T is risk for Type 2 diabetes) and rs7901695 (C is risk for Type 2 diabetes), respectively, as well as the homozygous genotypes TT, TT and CC of the rs7903146, rs12255372 and rs7901695, respectively, were strongly associated with gestational diabetes (P < 0.0001). 21672010

2011

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE T2D cases (n = 1140) and controls (n = 1915) from the Nurses' Health Study were genotyped for TCF7L2 (rs12255372). 19211816

2009

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE In conclusion, rs7903146 and rs12255372 were significantly associated with T2DM in the specified Northern Iranian population. 30776466

2019

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE The associations between SNPs of TCF7L2 (rs7903146 and rs12255372), SLC16A11 (rs13342232), and ABCA1 (rs9282541) with T2D were analyzed. 28101933

2017

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE We tested whether the expression of TCF7L2 splicing forms was associated with single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, located within introns 3 and 4 of the gene and most strongly associated with T2D. 19602480

2009

dbSNP: rs12255372
rs12255372
T 0.900 SusceptibilityMutation CLINVAR

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE The GG genotype at rs12255372 favourably influences treatment success with sulfonylurea therapy in patients with type 2 diabetes (p⩽0.05). 27639123

2016

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2 has been linked with type 2 diabetes among Caucasians, with disease associations noted for single nucleotide polymorphisms (SNPs) rs12255372 and rs7903146. 17130514

2006

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE Furthermore, we identified a common protective haplotype defined by these four SNPs that was significantly associated with type 2 diabetes and age at diagnosis (P = 4.2 x 10(-5), relative risk [RR] 0.69; P = 6.7 x 10(-6), respectively) and a haplotype that confers diabetes risk that contains the rare alleles at SNPs rs10885390 and rs12255372 (P = 0.02, RR 1.64). 17259383

2007

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE In addition, an association of two SNPs of the TCF7L2 gene with T2D was observed in both cities: rs7903146, (for Guerrero OR = 1.98 CI95% 1.02-3.89 and for Mexico OR = 1.94 CI95% 1.31-2.88) and rs12255372 (OR = 1.79 CI95% 1.08-2.97, OR = 1.78 CI95% 1.17-2.71 respectively). 21834909

2011

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE A total of 2,676 healthy European white middle-aged men from the prospective NPHSII (158 developed T2D over 15 years surveillance) were genotyped for two intronic SNPs [rs 7903146 (IVS3C>T) and rs12255372 (IVS4G>T)] which showed strong linkage disequilibrium (D' = 0.88, p<0.001; R(2)=0.76, p<0.001). 17665514

2006

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE PCOS carriers of the rs12255372 T (TCF7L2 Caucasian type 2 diabetes mellitus (T2D) locus) had no significant associated metabolic phenotypes. 22301903

2012

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE Using a case-control design, we examined whether the reported variants [rs12255372 (T/G) and rs7903146 (T/C)] are associated with type 2 diabetes in SEARCH for Diabetes in Youth study participants. 21109996

2011

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE There was no evidence that rs12255372G/T and rs290487T/C polymorphisms increased T2DM risk (T vs. G, OR = 1.77, 95% CI = 0.88-3.56; C vs. T, OR = 1.08, 95% CI = 0.93-1.25). 23527206

2013

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 are significantly associated with angiographically diagnosed CAD, specifically in patients with T2DM. 21423583

2011

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS. 29971604

2018

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE In this study we examined the associations between SNPs rs7901695, rs7903146 and rs12255372 in the TCF7L2 gene and metabolic variables affecting type 2 diabetes in a population-based study of 706 unrelated individuals (47% men and 53% women; aged 35-74 years) from the province of Segovia in central Spain (Castille), including 180 individuals with type 2 diabetes. 18712344

2008

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE We genotyped 309 German subjects at increased risk for type 2 diabetes for single nucleotide polymorphisms (SNPs) rs7903146, rs12255372, rs11196205, and rs7895340 in TCF7L2 and performed oral glucose tolerance tests before and after a 9-month lifestyle intervention. 20028944

2010

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation GWASDB A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. 17463248

2007

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE The previously reported SNPs rs7903146 T- and rs12255372 T-alleles of the TCF7L2 gene were rare and were not associated with type 2 diabetes in a Chinese population, which may attribute to the low frequencies of these two SNPs. 17579206

2007

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE The rs7903146 and rs12255372 variants of TCF7L2 have been strongly associated with type 2 diabetes (T2D) risk in most populations studied to date. 18655717

2008

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. 17245407

2007

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE Given the overlap between PCOS and T2DM, we investigated the association of transcription factor-7-like 2 (TCF7L2) variants rs4506565, rs7903146, rs12243326, and rs12255372 with the susceptibility to PCOS. 24157263

2014

dbSNP: rs12255372
rs12255372
0.900 GeneticVariation BEFREE In a prospective, nested, case-control study (n = 3,520) within the Nurses' Health Study (687 type 2 diabetic case and 1,051 control subjects) and the Health Professionals Follow-up Study (886 case and 896 control subjects), we examined the association of a common variant of the TCF7L2 gene (rs12255372 [T/G]) with type 2 diabetes risk among Caucasians. 16936216

2006