|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, the E23K variant was found to be significantly associated with Type II diabetes (0.001 < or = p < or = .00106, corrected p-values for multiple testing p < or = 0.01).
|
9867219 |
1998 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the present study, the association of the E23K polymorphism with type 2 diabetes was not significant (P = 0.26).
|
12540638 |
2003 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Meta-analysis of all case-control data showed that the E23K all</span>ele was associated with type 2 diabetes (K allele OR 1.23 [1.12-1.36], P = 0.000015; KK genotype 1.65 [1.34-2.02], P = 0.000002); but the ABCC8 variants were not associated.
|
12540637 |
2003 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2).
|
14988278 |
2004 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We conclude that the polymorphisms of the SUR1 gene predicted the conversion from impaired glucose tolerance to type 2 diabetes and that the effect of these polymorphisms on diabetes risk was additive with the E23K polymorphism of the Kir6.2 gene.
|
15579791 |
2004 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We show that E23K is also associated with decreased insulin secretion in glucose-tolerant control subjects, supporting a mechanism whereby beta-cell dysfunction contributes to the common form of type 2 diabetes.
|
15111507 |
2004 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes.
|
15797964 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These variants may contribute significantly to the risk type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys).
|
15715885 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The common KCNJ11 E23K gene variant, but not the ABCC8 exon 16 or exon 18 variant, was consistently associated with Type 2 diabetes.
|
15842514 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These data suggest that the E23K variant in KCNJ11 may influence the variability in the response of patients to sulfonylureas, thus representing an example of pharmacogenetics in type 2 diabetes.
|
16595597 |
2006 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data indicate that HNF4A P2 promoter polymorphisms may interact with KCNJ11 E23K in predicting Type 2 diabetes in women.
|
17894829 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Given the phenotypic overlap between PCOS and T2D, we investigated whether E23K is involved in susceptibility to PCOS and related traits.
|
17342155 |
2007 |
|
rs5219
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs5219
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs5219
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.
|
17259403 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta-analysis of East Asian studies, comprising a total of 3,357 T2D patients (77.4% Japanese) and 2,836 control subjects (77.8% Japanese), confirmed the significant role of the KCNJ11 E23K variant in T2D susceptibility.
|
17823772 |
2007 |
|
rs5219
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
All the polymorphic loci in KCNJ11 are in strong linkage disequilibrium in the Korean population and act as one haplotype block. g.67G>A and g.1009A>G were associated with an increased risk of Type 2 diabetes [age, sex, and body mass index (BMI)-adjusted odds ratios (OR) = 1.376 (1.085-1.745), P = 0.008 and 1.411 (1.111-1.791), P = 0.005, respectively], as was one haplotype (A-T-A-C-G-C in the order of polymorphisms as shown above) containing g.67A and g.1009G [OR = 1.359 (1.080-1.709), P = 0.009].
|
17257281 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The polymorphism E23K on KCNJ11 that is associated with NIDDM was differentially distributed in the 2 cohorts.
|
17727257 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Given the phenotypic overlap between PCOS and T2DM, our objective was to investigate whether the TCF7L2 rs7903146(C/T) and the KCNJ11 E23K variants are involved in susceptibility to PCOS and related traits in a Greek population.
|
18958766 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The P12A variant in the PPARG gene and the E23K polymorphism in KCNJ11 are both known to influence individual predisposition to type 2 diabetes.
|
17994213 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association of KCNJ11 E23K and ABCC8 exon16-3T/C with the therapeutic effect of repaglinide in patients with type 2 diabetes.
|
18664331 |
2008 |