|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.
|
17259403 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the East-Center of Tunisia was used to analyze the contribution to T2D of the following SNPs: E23K in KCNJ11/Kir6.2, K121Q in ENPP1, the -30G/A variant in the pancreatic beta-cell specific promoter of Glucokinase, rs7903146 in TCF7L2 encoding transcription factor 7-like2, and rs7923837 in HHEX encoding the homeobox, hematopoietically expressed transcription factor.
|
19368707 |
2009 |
|
rs5219
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs5219
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta-analysis of East Asian studies, comprising a total of 3,357 T2D patients (77.4% Japanese) and 2,836 control subjects (77.8% Japanese), confirmed the significant role of the KCNJ11 E23K variant in T2D susceptibility.
|
17823772 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A190A-TT or E23K-GG carriers had higher systolic blood pressure (SBP) than CC or AA carriers in the non-diabetic control and T2DM</span> groups (both p < 0.05).
|
25725792 |
2015 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ABCC8 exons 16 and 31 variants increase susceptibility to T2DM and KCNJ11 E23K decreases insulin secretion in a Turkish population.
|
22704848 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
All the polymorphic loci in KCNJ11 are in strong linkage disequilibrium in the Korean population and act as one haplotype block. g.67G>A and g.1009A>G were associated with an increased risk of Type 2 diabetes [age, sex, and body mass index (BMI)-adjusted odds ratios (OR) = 1.376 (1.085-1.745), P = 0.008 and 1.411 (1.111-1.791), P = 0.005, respectively], as was one haplotype (A-T-A-C-G-C in the order of polymorphisms as shown above) containing g.67A and g.1009G [OR = 1.359 (1.080-1.709), P = 0.009].
|
17257281 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable haplotype that is associated with an increased susceptibility to type 2 diabetes (T2D) risk.
|
22187380 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.
|
25165692 |
2014 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Conclusion Both dominant and additive models in both KCNJ11 (E23K, rs5219) and SDF-1β (G801A, rs1801157) genetic polymorphisms are significantly associated with type 2 diabetes.
|
29893194 |
2018 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For this reason, the present study looked at the contribution of ENNP1 (rs1044498), IGF2BP2 (rs1470579), KCNJ11 (rs5219), MLXIPL (rs7800944), PPARγ (rs1801282), SLC30A8 (rs13266634) and TCF7L2 (rs7903146) SNPs to the risk of T2DM in Lebanese and Tunisian Arabs.
|
22749234 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Four type 2 diabetes SNPs were associated with colorectal cancer risk: rs7578597 (THADA), rs864745 (JAZF1), rs5219 (KCNJ11) and rs7961581 (TSPAN8, LGR5).
|
21602532 |
2011 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic analysis revealed a novel variant (p.Pro190Leu) in HNF4A, which is located in the ligand binding domain of the transcription factor, and the p.Glu23Lys variant in KCNJ11, which is associated with type 2 diabetes.
|
26315042 |
2015 |
|
rs5219
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs5219
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies (GWAS) have reported that the polymorphism rs5219 of the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) is associated with type 2 diabetes mellitus (T2DM).
|
25573672 |
2015 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Given the phenotypic overlap between PCOS and T2D, we investigated whether E23K is involved in susceptibility to PCOS and related traits.
|
17342155 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Given the phenotypic overlap between PCOS and T2DM, our objective was to investigate whether the TCF7L2 rs7903146(C/T) and the KCNJ11 E23K variants are involved in susceptibility to PCOS and related traits in a Greek population.
|
18958766 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, rs5219 was not associated with type 2 diabetes in the Chinese Han population.
|
24065655 |
2013 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition to these polymorphisms, meta-analysis confirmed the association of type 2 diabetes susceptibility with KCNJ11 rs5219, TCF7L2 rs7903146, and HHEX rs1111875.
|
19033397 |
2009 |