Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13266634
rs13266634
C 1.000 GeneticVariation GWASCAT A genome-wide association study identifies novel risk loci for type 2 diabetes. 17293876

2007

dbSNP: rs13266634
rs13266634
C 1.000 GeneticVariation GWASCAT Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. 17463249

2007

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index. 20509872

2010

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE We replicated the association with type 2 diabetes for rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p=0.004), rs9939609 in FTO (OR 1.14, 95% CI: 1.04-1.25, p=0.006) and rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p=3.9 x 10(-4)). 18437351

2008

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE A significant association with type 2 diabetes was not observed for rs13266634. 17971426

2008

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE The variant rs13266634 in SLC30A8, encoding a β-cell-specific zinc transporter, is associated with type 2 diabetes. 24471563

2014

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE We estimate that the rs13266634 single nucleotide polymorphism, a type 2 diabetes susceptibility genotype, has a genetic prevalence of 56.3%, 47.4% and 37.0% in Mexican Mestizo, Caucasian, and Asian populations. 25875676

2015

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE Our results suggest that rs13266634 may be an important genetic factor of type 2 diabetes risk among Asian and European but not African populations. 26214053

2015

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE Our study suggested that the C allele of rs13266634 was associated with higher odds of T2D, and higher plasma zinc was associated with lower odds. 24306209

2014

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94). 18498634

2008

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE The R325W C-allele were more frequent in women with GDM compared to in controls (OR 1.47, 95 % CI 1.16-1.88, p = 0.0018) but not significantly increased in women with GDM and postpartum development of type 2 diabetes. 27003436

2016

dbSNP: rs13266634
rs13266634
C 1.000 GeneticVariation GWASCAT Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. 19401414

2009

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE The solute carrier family 30 member 8 gene (<i>SLC30A8</i>) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in <i>SLC30A8</i> is associated with an increased risk of type 2 diabetes (T2D). 29093761

2017

dbSNP: rs13266634
rs13266634
C 1.000 GeneticVariation GWASDB A genome-wide association study identifies novel risk loci for type 2 diabetes. 17293876

2007

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE SLC30A8 rs13266634 risk C allele frequency was higher in T2DM patients than in healthy controls (P < 0.05). 20809084

2010

dbSNP: rs13266634
rs13266634
C 1.000 GeneticVariation GWASCAT Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. 19734900

2009

dbSNP: rs13266634
rs13266634
T 1.000 SusceptibilityMutation CLINVAR

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE ZnT8 null mice have a mild phenotype with a slight decrease in glucose tolerance, whereas patients with the ZnT8 R325W polymorphism (rs13266634) have decreased proinsulin staining and susceptibility to T2DM. 27899481

2017

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE <b>Conclusion:</b> The present meta-analysis demonstrated that <i>SLC30A8</i> rs13266634 was a potential risk factor for T2DM, and more studies should be performed to confirm the association between rs13266634 polymorphism and IGR. 30319545

2018

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation GWASDB Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. 21874001

2011

dbSNP: rs13266634
rs13266634
C 1.000 GeneticVariation GWASCAT Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. 26818947

2016

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE SLC30A8 encodes a zinc transporter in the beta cell; individuals with a common missense variant (rs13266634; R325W) in SLC30A8 demonstrate a lower early insulin response to glucose and an increased risk of type 2 diabetes. 25348609

2015

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE The non-synonymous single nucleotide polymorphism (SNP) rs13266634 in human zinc transporter 8, ZnT8 (SLC30A8), leads to a R325 variant, which is associated with an increased risk of developing Type 2 Diabetes (T2D). 28965566

2017

dbSNP: rs13266634
rs13266634
1.000 GeneticVariation BEFREE Through sequencing or genotyping of ~150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels. 24584071

2014

dbSNP: rs13266634
rs13266634
C 1.000 GeneticVariation GWASCAT Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. 17463246

2007