rs1036483919
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Early-onset type 2 diabetes mellitus is associated to HNF4A T130I polymorphism in families of central Spain.
|
25361053 |
2014 |
rs1036483919
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Mutation p.T130I was associated with both early-onset and late-onset diabetes and caused downregulated HNF4A expression, whereas HNF1A polymorphisms p.I27L and p.S487N were associated with the age of diagnosis of diabetes.
|
26981542 |
2016 |
rs1799884
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Overall, the pooled results indicated that GCK (rs1799884), GCKR (rs780094) and MTNR1B (rs10830963) were significantly associated with T2DM susceptibility (OR, 1.04; 95%CI, 1.01-1.08; OR, 1.08; 95%CI, 1.05-1.12 and OR, 1.05; 95%CI, 1.02-1.08, respectively).
|
23840762 |
2013 |
rs1799884
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The GCK rs1799884 A allele was significantly associated with decreased HOMA-B (p([add]) = 0.0005), but not with type 2 diabetes or IFG.
|
19241058 |
2009 |
rs587780346
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent.
|
21978167 |
2012 |
rs730497
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association was observed between ESRD age of diagnosis and SNP rs730497, located in intron 1 of the GCK1 gene (recessive T2D age-adjusted P = 0.0006).
|
20144192 |
2010 |
rs1799884
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The SNP rs1799884 in the GCK promoter was associated with elevated fasting plasma glucose (fPG) concentrations that remained unchanged during the follow-up period (P = 0.4; SE 0.004 [-0.003-0.007]) but did not predict future type 2 diabetes (HR 0.9 [0.8-1.0], P = 0.1).
|
18332101 |
2008 |
rs4607517
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These seven tag SNPs and rs4607517, a type 2 diabetes variant established in other studies, were analysed in 415 full-heritage non-diabetic Pima Indians characterised for metabolic traits, and 7,667 American Indians who had data on type 2 diabetes and BMI.
|
24728127 |
2014 |
rs4607517
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1). rs340874 (PROX1) and rs174550 (FADS1) were significantly associated with T2D (P=0.0078, OR: 1.12; and P=0.0071, OR: 1.12, respectively).
|
22992776 |
2012 |