|
rs7903146
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.
|
30470734 |
2018 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The T2DM individuals carrying the rs7903146 T allele of the <i>TCF7L2</i> gene presented higher IR pattern in response to a mix-meal test, different of beta cell function at baseline assessed by C-peptide levels which was lower, and Homa-IR was lower when comparing with non-carriers.
|
29736187 |
2018 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNP rs7903146 at the transcription factor 7-like 2 (TCF7L2) locus is established as the strongest known genetic marker for type 2 diabetes via genome-wide association studies.
|
29331016 |
2018 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs7903146 T allele in transcription factor 7 like 2 (<i>TCF7L2</i>) is strongly associated with type 2 diabetes (T2D), but the mechanisms for increased risk remain unclear.
|
29326107 |
2018 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs7903146-T is associated with a decreased insulin concentration and increased risk of T2D with opposing effects of adjustment for adiposity.
|
29174029 |
2018 |
|
rs7903146
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.
|
30470734 |
2018 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, the additional presence of TCF7L2 rs7903146 risk alleles does not further aggravate the negative impact of a history of gestational diabetes on metabolic traits related to T2DM.
|
30419301 |
2018 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities.
|
29514658 |
2018 |
|
rs7903146
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Five SNPs in KCNQ1 (rs2237892), CDK2A/2B (rs108116610, SLC30A8 (rs13266634), TCF7L2 (rs7903146) and MTNR1B (rs1387153) were found to be marginally associated with risk of developing T2D, with odds ratios ranging from 1.43 to 2.02 (p = 0.047 to 3.0 × 10-4) with adjustments for age, sex, and body mass index.
|
29871606 |
2018 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We performed a family study and determined if the T risk allele of the rs7903146 in the TCF7L2 gene increases the risk of type 2 diabetes based on real-time stable isotope measurements of insulin synthesis during an Oral Glucose Tolerance Test.
|
29631902 |
2018 |
|
rs7903146
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
|
28254843 |
2017 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After adjusting for age, gender, drinking, smoking and body mass index (BMI), the association of <i>TCF7L2</i> rs7903146C>T and rs290481 T>C polymorphisms with T2DM was determined.
|
29100364 |
2017 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The associations between SNPs of TCF7L2 (rs7903146 and rs12255372), SLC16A11 (rs13342232), and ABCA1 (rs9282541) with T2D were analyzed.
|
28101933 |
2017 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
TCF7L2 variant rs7903146 is associated with increased risk for type 2 diabetes.
|
28183453 |
2017 |
|
rs7903146
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Contrary to previous studies, the key T2D risk allele at TCF7L2 (rs7903146-T) had a significantly lower frequency in LADA cases, suggesting that this locus does not play a role in LADA etiology.
|
28438156 |
2017 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The TCF7L2 rs7903146 T-allele shows the strongest association with type 2 diabetes (T2D) among common gene variants.
|
28220878 |
2017 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs7903146 variant in the <i>TCF7L2</i> gene increases the risk of IGT/T2D in obese adolescents by impairing β-cell function, and hepatic insulin sensitivity predicts the development of IGT/T2D over time.
|
28611053 |
2017 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNP rs7903146 in the Wnt pathway's TCF7L2 gene is the variant most significantly associated with type 2 diabetes to date, with associations observed across diverse populations.
|
28253288 |
2017 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs7903146-T allele in the transcription factor 7-like 2 (TCF7L2) gene has been associated with impaired pancreatic insulin secretion, enhanced liver glucose production, and an increased risk of type 2 diabetes.
|
26914832 |
2016 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After adjustment for potential contributory factors, nominally significant associations were seen between TT genotype and the recessive model of TCF7L2 rs7903146 and increased risk of T2DM [hazard ratio (HR)=4.068, 95% confidence interval (CI): 1.270-13.026; HR=4.051, 95% CI: 1.268-12.946, respectively].
|
27998387 |
2016 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Obesity significantly interacted with the TCF7L2-rs7903146 on T2D prevalence, associations being greater in non-obese subjects.
|
27929407 |
2016 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).
|
27053251 |
2016 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
By replicating the analysis of association with T2D between case-controls from the Sigma Project, we determined that T2D was most highly associated with the rs7903146 risk allele and to a lesser extent with the other six variants.
|
27230431 |
2016 |