|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant.
|
17827400 |
2007 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The G allele of rs1111875 (OR = 1.43, 95% CI = 1.18-1.72, p = 1.8 x 10(-4)) in HHEX), the T allele of rs10811661 (OR = 1.47, 95% CI = 1.23-1.75, p = 2.1 x 10(-5)) in CDKN2A/B) and the C allele of rs2237892 (OR = 1.31, 95% CI = 1.10-1.56, p = 0.003) in KCNQ1 showed significant associations with T2DM.
|
18991055 |
2008 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data, together with the meta-analysis of previously published studies, show that the rs10811661 polymorphism is associated with impaired insulin release and IGT, suggesting that this variant may contribute to type 2 diabetes by affecting beta cell function.
|
21234743 |
2011 |
|
rs10811661
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs10811661
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
rs10811661
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.
|
27189021 |
2016 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNPs in other genes such as rs7756992 in CDKAL1, rs10811661 in CDKN2B and rs13266634 in SLC30A8 showed nominal association with type 2 diabetes. rs7756992 in CDKAL1 and rs10811661 in CDKN2B were correlated with impaired pancreatic beta cell function as estimated by the homeostasis model assessment beta index (p = 0.023, p = 0.0083, respectively).
|
17928989 |
2007 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For the first time to our knowledge, our results indicated that the same 9p21.3 locus, represented by SNPs rs10811661 and rs10757283, contributed to the risk of type 2 diabetes and coronary artery disease in our GeneID Chinese Han population.
|
21270277 |
2011 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the association with type 2 diabetes for rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p=0.004), rs9939609 in FTO (OR 1.14, 95% CI: 1.04-1.25, p=0.006) and rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p=3.9 x 10(-4)).
|
18437351 |
2008 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNP rs10811661 of the CDKN2A/B gene was also associated with T2DM (allele T, P = 4.09 × 10(-7), OR = 1.36).
|
26139146 |
2015 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs5215, rs10811661, and rs2237892 were in significant association with T2DM, and hazard ratios per risk allele score increase were 1.11 (95% confidence intervals: 1.06-1.17), 1.09 (1.01-1.05), 1.04 (1.02-1.07) with GPS-3, GPS-18, GPS-36, respectively.
|
26240488 |
2015 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Seven SNPs in six genes known to increase the risk of T2DM in Caucasians were genotyped by means of TaqMan assays in 235 kidney transplant patients medicated with tacrolimus: rs4402960 and rs1470579 in IGF2BP2; rs1111875 in HHEX; rs10811661 upstream of CDKN2A/B; rs13266634 in SLC30A8; rs1801282 in PPARG; rs5215 in KCNJ11.
|
22569928 |
2012 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Because T2D is highly prevalent in Mexico, this study aimed to test the association of <i>CDKN2A/B</i>, <i>PPARGC1A</i>, <i>VEGFA</i>, <i>SIRT1</i> and <i>UCP2</i> gene polymorphisms (rs10811661, rs8192678, rs2010963, rs7896005 and rs659366 respectively) with metabolic traits in 415 unrelated Mexican mestizos with T2D under three models of inheritance.
|
30393491 |
2018 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We have not confirmed the association between rs10811661 SNP and susceptibility to the type 2 diabetes mellitus in Czech Slavonic population.
|
24093775 |
2013 |
|
rs10811661
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
23945395 |
2014 |
|
rs10811661
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For example, the most significant SNP, rs10811661 near CDKN2A/2B (P = 1.11×10(-8) for T2D), was also associated with 2-h glucose level of an oral glucose tolerance test (P = 9.11×10(-3)) and insulinogenic index (P = 2.71×10(-2)).
|
24637646 |
2014 |
|
rs10811661
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35.
|
21103332 |
2010 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two SNPs rs10811661 and rs928254 were significantly associated with T2D after adjusting for BMI; rs10811661 in a recessive and rs9282541 in a dominant model.
|
25839936 |
2015 |
|
rs10811661
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs10811661
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
23945395 |
2014 |