|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India.
|
22421923 |
2012 |
|
rs9939609
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
22693455 |
2012 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies have showed that common variant (rs9939609) in fat mass and obesity associated (FTO) gene was significantly associated with type 2 diabetes through an effect on human body mass index/obesity.
|
22311015 |
2012 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A total of 236 patients with type 2 diabetes (age: 60.0 ± 10.3 years; diabetes duration: 12.7 ± 8.2 years; 53.4% women) were genotyped for the FTO rs7204609 and rs9939609 polymorphisms (ABI PRISM 7000 Real-Time PCR System).
|
21741858 |
2012 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The FTO-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p = 9.0 × 10(-19)), overweight by 1.13-fold/allele (p = 1.0 × 10(-11)) and type 2 diabetes by 1.15-fold/allele (p = 5.5 × 10(-8)).
|
22109280 |
2012 |
|
rs9939609
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
22693455 |
2012 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These novel results suggest that the association of the FTO-rs9939609 and the MC4R-rs17782313 polymorphisms with type 2 diabetes depends on diet and that a high adherence to the MedDiet counteracts the genetic predisposition.
|
23130628 |
2012 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
|
22158537 |
2011 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The meta-analysis revealed a highly significant association for rs9939609 with both type 2 diabetes (OR 1.13; P = 4.5 × 10(-8)) and the risk to develop incident type 2 diabetes (OR 1.16; P = 3.2 × 10(-8)).
|
21398525 |
2011 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
None of the variants including previously reported intron 1 variants (rs1421085, rs8050136, rs9939609 and rs9930506) showed body mass index (BMI)-dependent/independent association with type 2 diabetes.
|
21814223 |
2011 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We analysed rs9939609 in two studies of Pakistani individuals: 1666 adults aged ≥40 years from the Karachi population-based Control of Blood Pressure and Risk Attenuation (COBRA) study and 2745 individuals of Punjabi ancestry who were part of a Type 2 diabetes case-control study (UK Asian Diabetes Study/Diabetes Genetics in Pakistan; UKADS/DGP).
|
21294771 |
2011 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Previous genome-wide association studies for type 2 diabetes susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated (FTO) gene region is associated with body mass index (BMI) in European children and adults.
|
20598163 |
2010 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The fat mass- and obesity-associated gene rs9939609 SNP is strongly associated with risk of obesity and newly diagnosed T2D in the Chinese population.
|
20186840 |
2010 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings indicate that the two variants (rs9939609 and rs8050136) in the FTO gene contribute to obesity and T2D in the Asian populations.
|
20057365 |
2010 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The increased fat mass in carriers of the A allele of rs9939609 of FTO is associated not only with increased risk of type 2 diabetes, but also with an increase in atherogenic lipid profile and myocardial infarction in these patients.
|
20031593 |
2009 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, no significant association was found between genetics and risk of type 2 diabetes after control of potential confounders (at least for BMI) either for rs9939609 (fixed effect OR=1.05, 95% CI=0.97,1.13) or for rs8050136 polymorphism (fixed effect OR =1.07, 95%CI: 0.99, 1.16).
|
20337217 |
2009 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent studies identified the rs9939609 A-allele of the FTO (fat mass and obesity associated) gene as being associated with obesity and type 2 diabetes.
|
18984658 |
2009 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed a strong association of the minor allele A at rs9939609 with type 2 diabetes (OR per allele 1.26; 95% CI 1.13-1.40; p = 3 x 10(-5)).
|
19005641 |
2009 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, the homozygous AA genotype of rs9939609 was associated with a higher risk of type 2 diabetes mellitus (odds ratio = 1.45 [1.05-1.99], P = .02, 283 subjects with and 2601 subjects without type 2 diabetes mellitus), independently of BMI.
|
19375760 |
2009 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The FTO rs9939609 polymorphism was genotyped in two twin cohorts: 1) 298 elderly twins aged 62-83 years with glucose tolerance ranging from normal to type 2 diabetes and 2) 196 young (25-32 years) and elderly (58-66 years) nondiabetic twins examined by a hyperinsulinemic-euglycemic clamp including indirect calorimetry.
|
19587359 |
2009 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults.
|
18335027 |
2008 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the association with type 2 diabetes for rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p=0.004), rs9939609 in FTO (OR 1.14, 95% CI: 1.04-1.25, p=0.006) and rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p=3.9 x 10(-4)).
|
18437351 |
2008 |
|
rs9939609
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In studies of 3,856 type 2 diabetic case subjects and 4,861 normal glucose-tolerant control subjects, the minor A-allele of rs9939609 associated with type 2 diabetes (odds ratio 1.13 [95% CI 1.06-1.20], P = 9 x 10(-5)).
|
17942823 |
2008 |