|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable haplotype that is associated with an increased susceptibility to type 2 diabetes (T2D) risk.
|
22187380 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNJ11 E23K polymorphism was associated with type 2 diabetes in genetic association studies.
|
22385882 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
|
22209866 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ABCC8 exons 16 and 31 variants increase susceptibility to T2DM and KCNJ11 E23K decreases insulin secretion in a Turkish population.
|
22704848 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study has provided supporting evidence for the role of the E23K variant in glycaemic progression in Chinese, with its effect being more evident in the early stage of T2DM, as the subjects progressed from normal glucose tolerance to prediabetes.
|
22163043 |
2011 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Four type 2 diabetes SNPs were associated with colorectal cancer risk: rs7578597 (THADA), rs864745 (JAZF1), rs5219 (KCNJ11) and rs7961581 (TSPAN8, LGR5).
|
21602532 |
2011 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes.
|
20054294 |
2010 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data suggest that patients with T2D carrying the K variant of the E23K polymorphism in KCNJ11 have reduced response to sulfonylurea therapy, which results in increased HbA(1c) and consequently in lower risk for SH.
|
19214942 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our investigation confirmed the association between the KCNJ11 E23K variant and type </span>2 diabetes under a recessive model (KK vs EK+EE) in the Chinese Han population (odds ratio (OR)=1.25, 95% confidence interval (95% CI) 1.04-1.50, P=0.017).
|
19498446 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study replicated the association of rs5219 in KCNJ11 with type 2 diabetes in Chinese Han population in Beijing.
|
20079163 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The KCNJ11 E23K and ABCC8 exon 31 variants contribute to susceptibility to T2D diabetes, glucose intolerance and altered insulin secretion in a Russian population.
|
18758683 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the East-Center of Tunisia was used to analyze the contribution to T2D of the following SNPs: E23K in KCNJ11/Kir6.2, K121Q in ENPP1, the -30G/A variant in the pancreatic beta-cell specific promoter of Glucokinase, rs7903146 in TCF7L2 encoding transcription factor 7-like2, and rs7923837 in HHEX encoding the homeobox, hematopoietically expressed transcription factor.
|
19368707 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs5219 (E23K) in KCNJ11 was associated with genetic susceptibility to type 2 diabetes (OR = 1.400 with 95% CI 1.117 1.755, P = 0.004 under an additive model, OR = 1.652 with 95% CI 1.086 2.513, P = 0.019 under a recessive model, and OR = 1.521 with 95% CI 1.089 2.123, P = 0.014 under a dominant model) after adjusting for sex and body mass index (BMI).
|
20079163 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition to these polymorphisms, meta-analysis confirmed the association of type 2 diabetes susceptibility with KCNJ11 rs5219, TCF7L2 rs7903146, and HHEX rs1111875.
|
19033397 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Given the phenotypic overlap between PCOS and T2DM, our objective was to investigate whether the TCF7L2 rs7903146(C/T) and the KCNJ11 E23K variants are involved in susceptibility to PCOS and related traits in a Greek population.
|
18958766 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The P12A variant in the PPARG gene and the E23K polymorphism in KCNJ11 are both known to influence individual predisposition to type 2 diabetes.
|
17994213 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association of KCNJ11 E23K and ABCC8 exon16-3T/C with the therapeutic effect of repaglinide in patients with type 2 diabetes.
|
18664331 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results report for the first time a positive association of the E23K variant with T2D in an Arab population.
|
17922473 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data indicate that HNF4A P2 promoter polymorphisms may interact with KCNJ11 E23K in predicting Type 2 diabetes in women.
|
17894829 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Given the phenotypic overlap between PCOS and T2D, we investigated whether E23K is involved in susceptibility to PCOS and related traits.
|
17342155 |
2007 |
|
rs5219
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |