|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta-analysis of East Asian studies, comprising a total of 3,357 T2D patients (77.4% Japanese) and 2,836 control subjects (77.8% Japanese), confirmed the significant role of the KCNJ11 E23K variant in T2D susceptibility.
|
17823772 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Four type 2 diabetes SNPs were associated with colorectal cancer risk: rs7578597 (THADA), rs864745 (JAZF1), rs5219 (KCNJ11) and rs7961581 (TSPAN8, LGR5).
|
21602532 |
2011 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the East-Center of Tunisia was used to analyze the contribution to T2D of the following SNPs: E23K in KCNJ11/Kir6.2, K121Q in ENPP1, the -30G/A variant in the pancreatic beta-cell specific promoter of Glucokinase, rs7903146 in TCF7L2 encoding transcription factor 7-like2, and rs7923837 in HHEX encoding the homeobox, hematopoietically expressed transcription factor.
|
19368707 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Meta-analysis of all case-control data showed that the E23K all</span>ele was associated with type 2 diabetes (K allele OR 1.23 [1.12-1.36], P = 0.000015; KK genotype 1.65 [1.34-2.02], P = 0.000002); but the ABCC8 variants were not associated.
|
12540637 |
2003 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We included 44 original studies published by June 2014 in a meta-analysis of the p.E23K association with T2DM.
|
25955821 |
2015 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results revealed the risk of type 2 diabetes conferred by KCNJ11 E23K gene variant in the Mauritanian population.
|
24332549 |
2014 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These data suggest that the E23K variant in KCNJ11 may influence the variability in the response of patients to sulfonylureas, thus representing an example of pharmacogenetics in type 2 diabetes.
|
16595597 |
2006 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNJ11 E23K polymorphism was associated with type 2 diabetes in genetic association studies.
|
22385882 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.
|
25165692 |
2014 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
They also aid our understanding of how the Kir6.2-E23K variant predisposes to type 2 diabetes.
|
27118464 |
2016 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNJ11 rs5219 is not independently associated with T2D in South-Indian population and our meta-analysis suggests that KCNJ11 polymorphism (rs5219) is associated with risk of T2D in East Asian population and global population but this outcome could not be replicated in South Asian sub groups.
|
25247988 |
2014 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For this reason, the present study looked at the contribution of ENNP1 (rs1044498), IGF2BP2 (rs1470579), KCNJ11 (rs5219), MLXIPL (rs7800944), PPARγ (rs1801282), SLC30A8 (rs13266634) and TCF7L2 (rs7903146) SNPs to the risk of T2DM in Lebanese and Tunisian Arabs.
|
22749234 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study has provided supporting evidence for the role of the E23K variant in glycaemic progression in Chinese, with its effect being more evident in the early stage of T2DM, as the subjects progressed from normal glucose tolerance to prediabetes.
|
22163043 |
2011 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Lys23Lys/CC combination was associated with a 2.65-fold increased likelihood of T2D (OR = 2.65, 95% CI 1.12-6.28), whereas the Glu23Lys/CT combination also increased such likelihood (OR = 3.88, 95% CI 1.27-11.91).
|
30467975 |
2019 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The common KCNJ11 E23K gene variant, but not the ABCC8 exon 16 or exon 18 variant, was consistently associated with Type 2 diabetes.
|
15842514 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using the random-effects model, we found a significant association between E23K (rs5219) polymorphism and T2D risk with per-allele odds ratio of 1.13 (95% confidence interval: 1.10-1.15; p<10(-5)).
|
22082043 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The P12A variant in the PPARG gene and the E23K polymorphism in KCNJ11 are both known to influence individual predisposition to type 2 diabetes.
|
17994213 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study showed that rs5219 polymorphism of the KCNJ11 gene is an important risk factor for type 2 diabetes mellitus in a sample of the Syrian population.
|
31195986 |
2019 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results suggest that E23K may have a greater effect on the development of T2D in female Chinese youth.
|
28449408 |
2018 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, rs5219 was not associated with type 2 diabetes in the Chinese Han population.
|
24065655 |
2013 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data suggest that patients with T2D carrying the K variant of the E23K polymorphism in KCNJ11 have reduced response to sulfonylurea therapy, which results in increased HbA(1c) and consequently in lower risk for SH.
|
19214942 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A190A-TT or E23K-GG carriers had higher systolic blood pressure (SBP) than CC or AA carriers in the non-diabetic control and T2DM</span> groups (both p < 0.05).
|
25725792 |
2015 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results report for the first time a positive association of the E23K variant with T2D in an Arab population.
|
17922473 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We show that E23K is also associated with decreased insulin secretion in glucose-tolerant control subjects, supporting a mechanism whereby beta-cell dysfunction contributes to the common form of type 2 diabetes.
|
15111507 |
2004 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Given the phenotypic overlap between PCOS and T2D, we investigated whether E23K is involved in susceptibility to PCOS and related traits.
|
17342155 |
2007 |