|
rs182052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Prevalence of type 2 diabetes mellitus was higher in subjects with the rs182052 A allele (OR = 2.29; 95%CI 1.29-4.21; <i>p</i> = 0.024).
|
31561637 |
2019 |
|
rs182052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Furthermore, the synergistic interaction between β-HCH and r</span>s182052 significantly increased T2DM risk (OR <sub>I-additive model</sub> = 2.20, OR <sub>I-recessive model</sub> = 2.13).
|
27883041 |
2016 |
|
rs182052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, 2-site haplotype analysis in the ADIPOQ locus using only 2 marginally associated SNPs (AD/rs182052 and AD/rs7649121) revealed a significant protective association of the GA haplotype with T2D (P = .009, permutation P = .026).
|
19846176 |
2010 |
|
rs182052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The SNP rs182052 in intron 1 of the adiponectin gene is associated with type 2 diabetes in African Americans.
|
19056609 |
2009 |
|
rs16861194
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, due to the limited sample size, only the rs16861194 exerted a significant increased risk on T2DM.
|
29101068 |
2018 |
|
rs16861194
|
|
|
0.050 |
GeneticVariation |
BEFREE |
When T2D cohort was further stratified according to the obesity status, PPARγ2 (rs1801282) and FTO (rs9939609) showed association with T2D only in the obese diabetic group and ADIPOQ (rs16861194) showed no difference in risk of susceptibility to the disease.
|
26243686 |
2016 |
|
rs16861194
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To derive a more precise estimation, we performed a meta-analysis to assess the association between five AdipoQ polymorphisms [-11426A > G (rs16861194), -11391G > A (rs17300539), -11377C > G (rs266729), +45T > G (rs2241766) and +276G > T (rs1501299)], and T2DM risk.
|
23653335 |
2013 |
|
rs16861194
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only.
|
22497971 |
2012 |
|
rs16861194
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects. rs16861194 (-11426 A>G) in the putative promoter of ADIPOQ was associated with T2DM (P = 0.007; OR = 1.29, 95%CI 1.08-1.55).
|
19631916 |
2009 |
|
rs17300539
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Meta-analysis showed only rs266729 and rs17300539</span> of ADIPOQ, and rs1884613, rs2144908, and rs4810424 of HNF4A were significantly associated with T2D risk.
|
30860284 |
2019 |
|
rs17300539
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.
|
26999420 |
2016 |
|
rs17300539
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The -3971 A/G (rs822396) and -11391 G/A (rs17300539) SNPs' association with T2DM diabetes was mediated through obesity (where the association with type 2 diabetes was lost after adjusting for BMI).
|
24055485 |
2013 |
|
rs17300539
|
|
|
0.060 |
GeneticVariation |
BEFREE |
To derive a more precise estimation, we performed a meta-analysis to assess the association between five AdipoQ polymorphisms [-11426A > G (rs16861194), -11391G > A (rs17300539), -11377C > G (rs266729), +45T > G (rs2241766) and +276G > T (rs1501299)], and T2DM risk.
|
23653335 |
2013 |
|
rs17300539
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs1730</span>0539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only.
|
22497971 |
2012 |
|
rs17300539
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes.
|
21638131 |
2011 |
|
rs1501299
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, we concluded on the basis of observed results that the ADIPOQ gene polymorphisms rs822396 and rs1501299 plays an important role in the development of type 2 diabetes in North Indian Punjabi population.
|
31755094 |
2019 |
|
rs1501299
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM.
|
31128439 |
2019 |
|
rs1501299
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two individual polymorphisms (ADIPOQ rs1501299, KCNJ11 rs5219) were found to be associated with T2D.
|
30467975 |
2019 |
|
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM.
|
31299695 |
2019 |
|
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
T2D was significantly associated with promoter rs266729, rs17300539, rs1884613, rs2144908, and rs4810424, and the association of T2D risk were affected by study population, diagnostic criteria, and genotype methods.
|
30860284 |
2019 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.
|
29686595 |
2018 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2241766T>G SNP of adiponectin gene is a risk factor for the development of T2DM in Iraqi population and directs the changes of serum lipid concentrations as well as insulin resistance.
|
29627525 |
2018 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control study was conducted to assess the association of rs2241766 and rs822395 SNPs of adiponectin gene (ADIPOQ) with T2DM in Iraqi population.
|
29627525 |
2018 |
|
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sources of control populations were the cause of between-study heterogeneity; nonetheless, there was no publication bias among studies.The G allele of rs266729 in adiponectin gene increases the risk of T2DM through an additive genetic model with an effect of 1.13 (1.06, 1.19).
|
29381968 |
2017 |
|
rs1501299
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study observed that the SNPs rs3792267 in CAPN10, rs1501299 in APM1, and rs3760776 in FUT6 might serve as potential susceptible biomarkers for T2DM in Uyghurs.
|
27374856 |
2016 |