|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control study was conducted to assess the association of rs2241766 and rs822395 SNPs of adiponectin gene (ADIPOQ) with T2DM in Iraqi population.
|
29627525 |
2018 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further, the ADIPOQ g. + 45 T > G and TNF-α g. - 308 G > A polymorphisms jointly give 1.45-fold risk towards T2D.
|
24655058 |
2014 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To derive a more precise estimation, we performed a meta-analysis to assess the association between five AdipoQ polymorphisms [-11426A > G (rs16861194), -11391G > A (rs17300539), -11377C > G (rs266729), +45T > G (rs2241766) and +276G > T (rs1501299)], and T2DM risk.
|
23653335 |
2013 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.
|
24825737 |
2015 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes.
|
21638131 |
2011 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only.
|
22497971 |
2012 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects.
|
15842511 |
2005 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Together, our data support that the rs2241766 and rs1501299 polymorphisms within the ADIPOQ gene confer genetic susceptibility for type 2 diabetes, especially in the Chinese Han population.
|
25135112 |
2014 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this case-control study, the associations of rs2241766 T/G of ADIPOQ, rs9289231 T/G of KALRN, and rs9939609 A/T of FTO polymorphisms with genetic susceptibility to CAD in type 2 diabetic (T2D) patients were investigated.
|
27218147 |
2016 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The adiponectin gene 45T/G mutation may be an important determinant of type 2 diabetes in the Iranian population.
|
22187345 |
2012 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Adiponectin gene polymorphism 45T>G is associated with carotid artery plaques in patients with type 2 diabetes mellitus.
|
18191060 |
2008 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2241766T>G SNP of adiponectin gene is a risk factor for the development of T2DM in Iraqi population and directs the changes of serum lipid concentrations as well as insulin resistance.
|
29627525 |
2018 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.
|
29686595 |
2018 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results show that T45G and G276T polymorphisms of ADPN are associated with a significantly elevated risk of DPN in T2DM patients, likely by down-regulating ADPN serum level.
|
26144281 |
2016 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that the GG genotype at rs2241766 is implicated in the pathogenesis of risk for diabetic nephropathy defined as UACR greater than 30 mg/day in patients with T2DM.
|
23260797 |
2013 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes.
|
17973869 |
2007 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The two SNPs (45T-->G and 276G-->T) were chosen because of their association with type 2 diabetes in Japanese.
|
12086965 |
2002 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs266729 C allele and the rare minor alleles of rs2241766 and rs2082940 were associated with an increased adjusted hazard ratio of developing T2DM.
|
21219602 |
2011 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that the adiponectin allele 45T/G and -11377C/G polymorphisms are significantly associated with the therapeutic efficacy of multiple-dose rosiglitazone in Chinese patients with T2D.
|
18429970 |
2008 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our results demonstrated that, adiponectin SNP 45T/G, rather than SNP 276G/T, is more associated with risk of T2DM in obese individuals.
|
19929719 |
2009 |
|
rs2241766
|
|
|
0.100 |
GeneticVariation |
BEFREE |
None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies.
|
19631916 |
2009 |
|
rs2082940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs266729 C allele and the rare minor alleles of rs2241766 and rs2082940 were associated with an increased adjusted hazard ratio of developing T2DM.
|
21219602 |
2011 |
|
rs185847354
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that I164T mutation is associated with low plasma adiponectin concentration and type 2 diabetes.
|
12086969 |
2002 |
|
rs182052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, 2-site haplotype analysis in the ADIPOQ locus using only 2 marginally associated SNPs (AD/rs182052 and AD/rs7649121) revealed a significant protective association of the GA haplotype with T2D (P = .009, permutation P = .026).
|
19846176 |
2010 |
|
rs182052
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Prevalence of type 2 diabetes mellitus was higher in subjects with the rs182052 A allele (OR = 2.29; 95%CI 1.29-4.21; <i>p</i> = 0.024).
|
31561637 |
2019 |