Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM. 31299695

2019

dbSNP: rs10811661
rs10811661
C 0.900 GeneticVariation GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458

2018

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE Because T2D is highly prevalent in Mexico, this study aimed to test the association of <i>CDKN2A/B</i>, <i>PPARGC1A</i>, <i>VEGFA</i>, <i>SIRT1</i> and <i>UCP2</i> gene polymorphisms (rs10811661, rs8192678, rs2010963, rs7896005 and rs659366 respectively) with metabolic traits in 415 unrelated Mexican mestizos with T2D under three models of inheritance. 30393491

2018

dbSNP: rs10811661
rs10811661
C 0.900 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590

2017

dbSNP: rs10811661
rs10811661
T 0.900 GeneticVariation GWASCAT Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 26961502

2016

dbSNP: rs10811661
rs10811661
T 0.900 GeneticVariation GWASCAT Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility. 27189021

2016

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE There were potential interactions among CDKN2A/2B (rs10811661) - FTO (rs7195539) or FTO (rs7195539)-TG-HDL-family history of diabetes in the pathogenesis of T2D in a Uyghur population. 26873362

2016

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE Two SNPs rs10811661 and rs928254 were significantly associated with T2D after adjusting for BMI; rs10811661 in a recessive and rs9282541 in a dominant model. 25839936

2015

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE The SNP rs10811661 of the CDKN2A/B gene was also associated with T2DM (allele T, P = 4.09 × 10(-7), OR = 1.36). 26139146

2015

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE Rs5215, rs10811661, and rs2237892 were in significant association with T2DM, and hazard ratios per risk allele score increase were 1.11 (95% confidence intervals: 1.06-1.17), 1.09 (1.01-1.05), 1.04 (1.02-1.07) with GPS-3, GPS-18, GPS-36, respectively. 26240488

2015

dbSNP: rs10811661
rs10811661
T 0.900 GeneticVariation GWASDB Genome-wide association study identifies three novel loci for type 2 diabetes. 23945395

2014

dbSNP: rs10811661
rs10811661
T 0.900 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

dbSNP: rs10811661
rs10811661
T 0.900 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

dbSNP: rs10811661
rs10811661
T 0.900 GeneticVariation GWASCAT Genome-wide association study identifies three novel loci for type 2 diabetes. 23945395

2014

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE For example, the most significant SNP, rs10811661 near CDKN2A/2B (P = 1.11×10(-8) for T2D), was also associated with 2-h glucose level of an oral glucose tolerance test (P = 9.11×10(-3)) and insulinogenic index (P = 2.71×10(-2)). 24637646

2014

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE The meta-analysis indicated that rs10811661 polymorphism was significantly associated with the risk of type 2 diabetes. 22623142

2013

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE Single nucleotide polymorphisms in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation. 23298195

2013

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE In meta-regression analyses, age was found to exert a significant influence on the association between rs10811661 and type 2 diabetes (P=0.003), as well as between rs7754840 and gender (P=0.034). 24012816

2013

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE We have not confirmed the association between rs10811661 SNP and susceptibility to the type 2 diabetes mellitus in Czech Slavonic population. 24093775

2013

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012

dbSNP: rs10811661
rs10811661
T 0.900 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160

2012

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE A relatively small but significant role of the T allele of the rs10811661 SNP in increasing by 21-27% the risk of T2D in an additive way was apparent. 21315566

2012

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE The association between rs10811661 T allele and T2D was observed both in Asia (P < 1 × 10(-4)) and Europe ethnicity groups (P = 0.002). 21625859

2012

dbSNP: rs10811661
rs10811661
0.900 GeneticVariation BEFREE To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609. 22377712

2012