Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05. 31759989

2020

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE The finding revealed the all measured inheritance models of rs1111875G/A and of rs5015480C/T variants dramatically increase the risk of T2D while another polymorphism (rs7923837A/G) was not associated with risk/protective role in T2D. 31237015

2019

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE However, no significant association was detected between HHEX (rs1111875), CDKAL1 (rs7756992), or UBE2E2 (rs7612463) and T2D. 29871606

2018

dbSNP: rs1111875
rs1111875
T 0.900 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590

2017

dbSNP: rs1111875
rs1111875
C 0.900 GeneticVariation GWASCAT Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 26961502

2016

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D. 25839936

2015

dbSNP: rs1111875
rs1111875
C 0.900 GeneticVariation GWASCAT Genome-wide association study identifies three novel loci for type 2 diabetes. 23945395

2014

dbSNP: rs1111875
rs1111875
C 0.900 GeneticVariation GWASDB Genome-wide association study identifies three novel loci for type 2 diabetes. 23945395

2014

dbSNP: rs1111875
rs1111875
C 0.900 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

dbSNP: rs1111875
rs1111875
C 0.900 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents. 24062323

2014

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE Five risk variants in IGF2BP2 (rs4402960, rs1470579), CDKAL1 (rs10946398), SLC30A8 (rs13266634), and HHEX (rs1111875) genes were nominally associated with T2DM in our samples. 24736664

2014

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE Variants in the KCNQ1 (rs2237895, p = 0.0012), HHEX (rs1111875, p = 0.0024 in Finns) and MTNR1B (rs10830963, p = 0.0039) loci showed the strongest association in patients with low GADA, supporting the hypothesis that the disease in these patients is more like type 2 diabetes. 24906951

2014

dbSNP: rs1111875
rs1111875
C 0.900 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609. 22377712

2012

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE A cumulative effect of rs7923837 and rs1111875 was observed with individuals carrying 1, 2, and 3 or 4 risk alleles having a 1.27, 1.44, and 1.73-fold increased risk, respectively, for type 2 diabetes (P for trend = 4.1E-10). 22506066

2012

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE Seven SNPs in six genes known to increase the risk of T2DM in Caucasians were genotyped by means of TaqMan assays in 235 kidney transplant patients medicated with tacrolimus: rs4402960 and rs1470579 in IGF2BP2; rs1111875 in HHEX; rs10811661 upstream of CDKN2A/B; rs13266634 in SLC30A8; rs1801282 in PPARG; rs5215 in KCNJ11. 22569928

2012

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE Our results provide clarification to the significant association of rs1111875, rs5015480 and rs7923837 in HHEX gene with type 2 diabetes. 23166797

2012

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation GWASDB Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. 21647700

2011

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE This meta-analysis demonstrated that the C allele of rs1111875 of HHEX is a risk factor associated with increased T2D susceptibility, but these associations vary in different ethnic populations. 21056935

2011

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE This meta-analysis demonstrated that the risk allele of HHEX polymorphisms (rs1111875 and rs7923837) is a risk factor for developing T2D. 21059810

2011

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE The HHEX-IDE rs1111875 variant showed no significant association among Danes (p = 0.09); however, in a meta-analysis (n = 25,164) this type 2 diabetes risk allele was associated with lower birthweight (beta = -16 g [95% CI -24, -8], p = 8 x 10(-5)). 20490451

2010

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied. 20550665

2010

dbSNP: rs1111875
rs1111875
0.900 GeneticVariation BEFREE In addition, the meta-analysis (7207 cases and 8260 controls) also showed that HHEX rs1111875 did have effects on type 2 diabetes in Chinese population (OR=1.15(1.10-1.21); P=1.93 × 10(-8)). 20927120

2010