|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The meta-analysis results demonstrated that TCF7L2 rs4506565, rs7901695, rs11196205 and rs12255372 polymorphisms were all significantly associated with susceptibility to T2DM in general population.
|
31288068 |
2020 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005).
|
31676834 |
2019 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The purpose of this study was to assess the association between TCF7L2 variants (rs7903146, rs11196205, and rs11255372) and T2DM by TaqMan assay.
|
30776466 |
2019 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms (rs290487, rs7903146, rs11196205, and rs12255372), closely associated with type 2 diabetes in the Eastern Asia population, were genotyped and analyzed.
|
23041303 |
2013 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 are significantly associated with angiographically diagnosed CAD, specifically in patients with T2DM.
|
21423583 |
2011 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We genotyped 309 German subjects at increased risk for type 2 diabetes for single nucleotide polymorphisms (SNPs) rs7903146, rs12255372, rs11196205, and rs7895340 in TCF7L2 and performed oral glucose tolerance tests before and after a 9-month lifestyle intervention.
|
20028944 |
2010 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The authors then performed a large meta-analysis of 36 studies examining the association of type 2 diabetes mellitus (T2DM) with polymorphisms in the TCF7L2 gene in various ethnicities, containing rs7903146 C-to-T (IVS3C>T), rs7901695 T-to-C (IVS3T>C), a rs12255372 G-to-T (IVS4G>T), and rs11196205 G-to-C (IVS4G>C) polymorphisms and to evaluate the size of gene effect and the possible genetic mode of action.
|
19228405 |
2009 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We found that four SNPs (rs7903146, rs12255372, rs11196205, rs290487) in TCF7L2 were significantly associated with T2DM in East Asian populations.
|
19482368 |
2009 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR=1.48, P=2.7 x 10(-4); OR=1.39, P=4.6 x 10(-4); OR=1.70, P=9.8 x 10(-5), respectively) in the combined sample sets.
|
18097733 |
2008 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We report replication of association of four of the six SNPs with T2DM in this Khatri Sikh sample [rs7903146, (p = 0.010); rs11196205, (p = 0.011); rs10885409, (p = 0.002) and rs4918789, (p = 0.029)], under a dominant model conferring odds ratios (ORs) of 1.39, 1.44, 1.57 and 1.36, respectively.
|
18397358 |
2008 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rest of the five SNPs (rs7895340, rs11196205 and rs12255372) did not show any significant associations with type 2 diabetes.
|
17245589 |
2007 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We compared genotype frequencies in subjects with type 2 diabetes with those with NGT and found marginal association for rs7901695 (P = 0.05; odds ratio [OR] 1.51); comparison between NGT control subjects and the combined type 2 diabetes/IGT case group showed strong association with rs7901695 and rs7903146 (P = 0.008-0.01; OR 1.53-1.57) and marginal association with rs11196205 and rs12255372 (P = 0.07 and P = 0.04, respectively).
|
16936218 |
2006 |
|
rs11196205
|
|
C |
0.800 |
SusceptibilityMutation |
CLINVAR |
|
|
|