|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For TCF7L2, the rs11196218 genotype GA and the haplotype CCG, TTG, TTA were associated with T2DM risk; whereas, the haplotype CTG and TCG were associated with decreased risk.
|
26083111 |
2015 |
|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The combined analysis indicated that the rs11196218A/G polymorphism was not associated with type 2 diabetes mellitus</span> (G vs. A, OR=1.04,</span> 95% CI=0.97-1.13, p=0.28).
|
26247673 |
2015 |
|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs11196218(IVS4G>A) and rs290487 (IVS3C>T) SNPs were not associated with T2DM risk.
|
23311683 |
2013 |
|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, no significant associations were found between the two polymorphisms (rs290487 and rs11196218) and type 2 diabetes.
|
23188737 |
2013 |
|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant association between rs11196218 and T2D.
|
22245614 |
2012 |
|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed single nucleotide polymorphisms (SNPs) rs11196218 and rs290487 of the TCF7L2 gene, which showed robust associations with T2D in Chinese population, in 430 PCOS patients and 360 control subjects by pyrosequencing, and also assessed the effect of genotype on clinical and biochemical traits in the PCOS group.
|
22296403 |
2012 |
|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control study was performed in Han Chinese subjects with normal control (n=152) and T2DM (n=227), we genotyped rs7903146 and rs11196218 at TCF7L2, rs13266634 at SLC30A8, rs3811951 at PCSK1 and rs2021785 at PCSK2.
|
21437630 |
2012 |
|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Novel risk loci for type 2 diabetes, single nucleotide polymorphism (SNP) rs7756992 in cyclin-dependent kinase 5 (CDK5) regulatory subunit associated protein 1-like 1 (CDKAL1), rs290487 and rs11196218 in transcription factor 7-like 2 (TCF7L2), were recently identified.
|
19718565 |
2010 |
|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Perform the meta-analysis of all the validated studies and evaluate the association between rs7903146 T allele, rs12255372 T allele, rs11196205 C allele, rs290487 C allele and rs11196218 G allele of TCF7L2 and the risk of T2DM.
|
19482368 |
2009 |
|
rs11196218
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interestingly, another SNP (rs11196218 G allele) located in adjacent LD block conferred independent risk for T2D [OR (95%CI) =1.43 (1.14-1.79)] and contributed high-population attributable risk of 42%.
|
17609304 |
2007 |