DisGeNET - a database of gene-disease associations

Diabetes Mellitus, Non-Insulin-Dependent, C0011860

Variant: rs1137100 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs1137100

LEPR

0.040

GeneticVariation

BEFREE

Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM.

31128439

2019

dbSNP:

rs1137100

LEPR

0.040

GeneticVariation

BEFREE

The present meta-analysis did not detect significant genetic associations between LEPR Q223R and K109R polymorphisms and T2D risk.

29293570

2018

dbSNP:

rs1137100

LEPR

0.040

GeneticVariation

BEFREE

In the present study, we examined whether common single nucleotide polymorphisms (SNPs) in the leptin (LEP; 19G>A) gene and its receptor (LEPR; Q223R and K109R) are associated with birth weight and adult metabolic risk factors for type 2 diabetes in twins.

18490929

2008

dbSNP:

rs1137100

LEPR

0.040

GeneticVariation

BEFREE

Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT.

15997246

2005