|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assessment of the Pro12Ala Polymorphism in the PPAR-γ2 Gene among Type 2 Diabetes Patients in a Nigerian Population.
|
29621178 |
2018 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala (rs1801282) polymorphism in peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) has been convincingly associated with insulin resistance (IR) and type 2 diabetes (T2D) among Europeans, in interaction with a high-fat diet.
|
27075119 |
2016 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes.
|
25974167 |
2015 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also confirmed that Pro12Ala mutation in PPAR-γ2 is not associated with T2DM risk in this population.
|
26273662 |
2015 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Pro12Ala mutation decreases PPARG activity and resistance to NIDDM.
|
22937051 |
2012 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effects of the PPARG P12A and C161T gene variants on serum lipids in coronary heart disease patients with and without Type 2 diabetes.
|
21833536 |
2011 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Considering that the Pro12Ala polymorphism in the PPAR-gamma2 gene is one of the factors related to insulin sensitivity, the present study demonstrated a significant effect of the Ala allele on lower development of T2DM in Caucasians and greater sensitivity to insulin in overweight subjects.
|
20420754 |
2010 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis.
|
19766907 |
2009 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Pro12Ala polymorphism was genotyped by TaqMan-based assay in genomic DNA of 1,119 consenting patients from BErgamo NEphrologic DIabetic Complications Trial (BENEDICT)-a prospective, randomized trial evaluating ACE inhibition effect on new-onset microalbuminuria (albuminuria 20-200 microg/min in at least two of three consecutive overnight urine collections in two consecutive visits) in hypertensive type 2 diabetes with albuminuria <20 microg/min at inclusion.
|
19720797 |
2009 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A population-attributable risk of approximately 50% for the Pro12Pro genotype indicates that testing for the Pro12Ala of the PPARG gene in addition to the already identified clinical risk factors may become a useful tool to further reduce the risk of PPARgamma agonist-induced fluid retention and edema in patients with type 2 diabetes.
|
16822823 |
2006 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There is no association between Pro12Ala PPAR-gamma2 polymorphism and body mass changes observed during a course of type 2 diabetes, differences in peripheral insulin resistance and incidence and progression of diabetic complications in obese patients with long-lasting type 2 diabetes.
|
16824933 |
2006 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among obese people, there was no association between any of the T2Dm or obesity-related traits and the Pro12Ala polymorphism.
|
16050954 |
2005 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
|
15592662 |
2004 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala and the Pro12Pro variants in the PPAR-gamma gene are not associated with the response rate to pioglitazone treatment in patients with type 2 diabetes.
|
12610044 |
2003 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients.
|
11928067 |
2002 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study.
|
12145174 |
2002 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR-gamma2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated.
|
11793024 |
2001 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings support a role for the PPAR-gamma2 Pro12Ala variant in the etiology of type 2 diabetes and the insulin resistance syndrome.
|
11289057 |
2001 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The incidence of Type II diabetes and IGT among the Swedish subjects at the age of 70 was similar in the three genotype-groups of the Pro12Ala variant and the Ala-allele was not related to a lower prevalence of Type II diabetes in Danish Caucasians.
|
11596673 |
2001 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the PPARgamma is a thrifty gene and that the Pro12Ala PPARgamma2 polymorphism protects against type 2 diabetes in the Japanese.
|
10777704 |
2000 |
|
rs1232898090
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.
|
9425261 |
1997 |