Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17782313
rs17782313
0.090 GeneticVariation BEFREE The C/T polymorphism (rs17782313) mapped 188 kb downstream of the melanocortin-4 receptor gene (MC4R) shows a strong relationship with an increased body mass index (BMI) and the risk of type 2 diabetes. 28828082

2017

dbSNP: rs17782313
rs17782313
0.090 GeneticVariation BEFREE MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect. 24151814

2014

dbSNP: rs17782313
rs17782313
0.090 GeneticVariation BEFREE This study aimed to investigate the association of FTO rs9939609 and MC4R rs17782313 with anthropometric indexes, BP, and type 2 diabetes mellitus among hypertensive patients. 23849767

2013

dbSNP: rs17782313
rs17782313
0.090 GeneticVariation BEFREE These novel results suggest that the association of the FTO-rs9939609 and the MC4R-rs17782313 polymorphisms with type 2 diabetes depends on diet and that a high adherence to the MedDiet counteracts the genetic predisposition. 23130628

2012

dbSNP: rs17782313
rs17782313
0.090 GeneticVariation BEFREE The present meta-analysis confirmed the significant association of the rs17782313 polymorphism near the MC4R gene with type 2 diabetes risk, which was independent of BMI. 22869321

2012

dbSNP: rs17782313
rs17782313
0.090 GeneticVariation BEFREE We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India. 22421923

2012

dbSNP: rs17782313
rs17782313
0.090 GeneticVariation BEFREE The frequency of the minor risk alleles of rs17782313 and rs12970134 was higher among patients with type 2 diabetes than among glucose-tolerant individuals (OR 1.08, P = 0.08 and 1.08, P = 0.06, respectively); however, these borderline associations were abolished after adjustment for BMI. 19073769

2009

dbSNP: rs17782313
rs17782313
0.090 GeneticVariation BEFREE In the present study, we analyzed independent and combined effects of the FTO rs1421085 and MC4R rs17782313 risk alleles on BMI, fat mass, prevalence and incidence of obesity and subsequent type 2 diabetes (T2D) as well as their interactions with physical activity levels and gender in two European prospective population-based cohorts of 4,762 Finnish adolescents (NFBC 1986) and 3,167 French adults (D.E.S.I.R.). 19255736

2009

dbSNP: rs17782313
rs17782313
0.090 GeneticVariation BEFREE Moreover, per allele-C of rs17782313 was associated with 14% (2-32%) increased risk of type 2 diabetes, adjusting for BMI and other covariates. 18697794

2008