Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE Data showed no increased frequency of HFE mutations in persons with type 2 diabetes and no association between H63D mutation and NAFLD in the study population. 27894410

2016

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE An increased odds ratio for type 2 diabetes mellitus was observed in persons carrying a D allele at the H63D polymorphism compared with those with an H allele (odds ratio (OR) = 1.21, 95% confidence interval (CI): 1.03, 1.41; P = 0.02). 22908207

2012

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE Mutation H63D in the HFE gene was associated with a higher risk of type 2 DM, but did not appear to confer risk for diabetic chronic complications. 20097100

2011

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE C282Y and H63D are the main mutations related to hereditary hemochromatosis; these mutations have been reported to be associated with increased risk of developing diabetes mellitus type 2 (DM2). 19876870

2009

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE Our data indicate significant effects of H63D and C282Y on body iron stores and suggest a potential interaction between HFE genotypes and heme iron intake in relation to the risk of type 2 diabetes. 16306377

2005

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE We initiated the present work to determine whether the presence of the HFE C282Y or H63D mutations could be related to the clinical expression of diabetes mellitus type 2. 15347835

2004

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE The C282Y and H63D gene mutations were tested in 338 Caucasians with type 2 diabetes: 156 cases with CAD and 182 subjects with no history of CAD. 15222129

2004

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE We present data from the largest case-control study of the C282Y and H63D HFE allele frequencies in typical type 2 diabetes mellitus, as defined by an age of onset greater than 30 years and no requirement for insulin in the first year post-diagnosis. 12783844

2003

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE The results do suggest, however, that the H63D mutation may play a role in the pathogenesis of late onset T2DM and in males in this Polish population. 12601293

2003

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE In the present study, we searched for a relationship between C282Y and H63D gene mutations and the development of proliferative diabetic retinopathy in Caucasians with type 2 diabetes. 14618419

2003

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE Relations among serum ferritin, C282Y and H63D mutations in the HFE gene and type 2 diabetes mellitus in the Czech population. 12148086

2002

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE We performed an association study to assess the role of the C282Y and H63D mutations in the HFE gene as a risk factor for type 2 diabetes and diabetic nephropathy. 11423500

2001