Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801282
rs1801282
C 0.900 GeneticVariation GWASCAT Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. 29632382

2018

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D. 30064293

2018

dbSNP: rs1801282
rs1801282
G 0.900 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590

2017

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE These findings suggest no significant association of p.Pro12Ala polymorphism with retinopathy in tested type 2 diabetic retinopathy patients as compared to T2DM individuals take as controls. 27427939

2017

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE We found a significant association of Pro12Ala polymorphism of PPARγ2 gene with T2DM, however the genotypes showed statistically significant association only with few clinical parameters including body mass index, total cholesterol, and low-density lipoprotein (P < 0.05). 27567620

2017

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE The meta-analysis of PPARγ2 (rs1801282) showed population-specific association for T2D susceptibility as opposed to FTO (rs9939609) which showed no difference in population effect toward T2D susceptibility. 26243686

2016

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE Among type 2 diabetes mellitus SNPs, rs1801282 is of particular interest because (i) it is harbored by peroxisome proliferator-activated receptor-γ2 (PPARγ2), which is the target for thiazolidinediones which are used as antidiabetic drugs, decreasing all-cause mortality in type 2 diabetes mellitus, and (ii) it is associated with insulin resistance and related traits, risk factors for overall mortality in type 2 diabetes mellitus. 26956846

2016

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM. 26999420

2016

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE The Pro12Ala (rs1801282) polymorphism in peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) has been convincingly associated with insulin resistance (IR) and type 2 diabetes (T2D) among Europeans, in interaction with a high-fat diet. 27075119

2016

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE Variation in PPARG, but not Pro12Ala, contributes to declining SI and concomitant deterioration in β-cell function in Mexican Americans at risk for T2DM. 25584717

2015

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D. 25839936

2015

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE In a large sample of the Caucasians the rs8192673 of the PGC-1α gene and the rs1801282 of the PPAR-γ gene were associated with waist circumference in subjects with T2DM. 25928419

2015

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes. 25974167

2015

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE We conducted a case control study to confirm the association of variants rs10885409 of TCF7L2 and Pro12Ala (rs1801282) of PPAR-γ2 with risk of T2DM and related complications in Emirati population of Arab origin. 26273662

2015

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE We genotyped PPARγ Pro12Ala polymorphism in subjects with type 2 diabetes mellitus (T2DM). 26836268

2015

dbSNP: rs1801282
rs1801282
C 0.900 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

dbSNP: rs1801282
rs1801282
C 0.900 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE Nominal interactions were observed for sleep duration and PPARG rs1801282, CRY2 rs7943320 and HNF1B rs4430796 in influencing risk of type 2 diabetes (p < 0.05). 24280871

2014

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE We investigated the independent and joint effects of PPARG Pro12Ala and IRS1 Gly972Arg on markers of insulin resistance and T2DM in an African population with elevated risk of T2DM. 24447396

2014

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity. 24969838

2014

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE Hence, our aim was to develop a low-cost method for the validation of PPARG (Pro12Ala, CCA>GCA) SNP (rs1801282) for its association with T2D. 25063576

2014

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decreased risk of type 2 diabetes (T2D). 25157153

2014

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE The PPAR-γ2 gene rs1801282 polymorphism was significantly associated with type 2 diabetes susceptibility (OR=0.515, 95% CI 0.268-0.990) and the PTPRD gene rs17584499 polymorphism was also significantly associated with type 2 diabetes (OR=1.984, 95% CI 1.135-3.469) in a dominant model adjusted for age, gender and BMI. 23147557

2013

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE In a Mendelian randomization design, both HOMA-IR (instrumental variables: rs1801282, rs4607103) and βF (instrumental variable: rs4607103) were related to T2DM (p < 0.03-0.01 and p < 0.03, respectively). 23161442

2013

dbSNP: rs1801282
rs1801282
0.900 GeneticVariation BEFREE The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele. 23386649

2013