|
rs1884614
|
|
|
0.090 |
GeneticVariation |
BEFREE |
However, the frequency of haplotype, CCTA, built by rs4810424, rs1884613, rs1884614 and rs2144908 was significantly higher in the type 2 diabetes mellitus group compared with the control group (χ2=8.34, P=0.004).
|
26781905 |
2016 |
|
rs1884614
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In the case-control analysis, PPARG rs1801282 (Pro12Ala) (OR=1.48 (1.02-2.16)), ADIPOQ rs1063539 (OR=1.17 (1.01-1.35)), and HNF4A rs1884614 (OR=1.16 (1.00-1.32) were associated with T2D (P(allelic)<0.05).
|
22515931 |
2012 |
|
rs1884614
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Minor allele frequency of rs1884614 and rs2071197 was significantly lower in early onset T2DM when compared to NGT subjects (p < 0.01).
|
21062274 |
2011 |
|
rs1884614
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To summarize, our investigation did not confirm the effects of HNF4A variants (rs1884614 and rs2425637) on T2D risk, but found that the risk HNF4A contributed to T2D might be population specific.
|
20558840 |
2010 |
|
rs1884614
|
|
|
0.090 |
GeneticVariation |
BEFREE |
SNP rs1884614 in the P2 promoter region of the HNF-4alpha gene may influence insulin secretion in non-obese Japanese subjects with type 2 diabetes.
|
18654034 |
2008 |
|
rs1884614
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This study was aimed to assess the association of the two single nucleotide polymorphisms (SNPs) near P2 promoter (rs1884614 and rs2144908) of hepatocyte nuclear factor-4alpha (HNF4A) with insulin secretion index and type 2 diabetes in Thais.
|
17805472 |
2007 |
|
rs1884614
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The risk allele of the rs1884614, which is located 4 kb upstream of the HNF4A P2 promoter, was associated with type 2 diabetes (odds ratio [OR]=1.14, p=0.02) and with a subtle increase in post-OGTT plasma glucose levels in glucose-tolerant subjects (additive model, p=0.05).
|
15735891 |
2005 |
|
rs1884614
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In the P2 promoter, the htSNP rs1884614 showed borderline association with both type 2 diabetes (OR 1.40, P = 0.09) and the combined type 2 diabetes/IGT trait (1.35, P = 0.07).
|
15561969 |
2004 |
|
rs1884614
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Testing of additional SNPs 5' of rs1884614 revealed a >10-kb haplotype block that was associated with type 2 diabetes.
|
15047632 |
2004 |