|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis showed only rs266729 and rs17300539 of ADIP</span>OQ, and rs1884613, rs2144908, and rs4810424 of HNF4A were significantly associated with T2D risk.
|
30860284 |
2019 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the frequency of haplotype, CCTA, built by rs4810424, rs1884613, rs1884614 and rs2144908 was significantly higher in the type 2 diabetes mellitus group compared with the control group (χ2=8.34, P=0.004).
|
26781905 |
2016 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNPs rs4810424, rs1884613, and rs2144908 were associated with protection against type 2 diabetes without metabolic syndrome (recessive P = 0.018, OR 0.32; P = 0.004, OR 0.25; P = 0.005, OR 0.24, respectively).
|
21983932 |
2012 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the minor allele of the rs2144908 was significantly higher in subjects with MODY (p < 0.01) and that of rs736823 was significantly higher in early onset T2DM (p = 0.001).
|
21062274 |
2011 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HNF4A promoter P2 polymorphisms rs1884613 and rs2144908, which are in high linkage disequilibrium, showed significant association with type 2 diabetes (odds ratio (OR)=1.37 (95% confidence interval (CI) 1.19-1.57), P=9.4 × 10(-6) for rs1884613 and OR=1.37 (95%CI 1.20-1.57), P=6.0 × 10(-6) for rs2144908), as previously shown in other populations.
|
21814221 |
2011 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin (P = 0.004 under an additive model for rs2144908; and P = 0.001 under a dominant model for rs2144908) after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala.
|
20079163 |
2009 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Combined analysis of both phases demonstrated association between HNF4A P2 SNPs (rs1884613 and rs2144908) and type 2 diabetes in the Ashkenazim (n = 991; P < 1.6 x 10(-6)).
|
18728231 |
2008 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the Japanese population, a haplotype consisting of two SNPs (rs1884614 and rs2144908) in the P2 promoter region is reported to show a significant association with type 2 diabetes.
|
18654034 |
2008 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study was aimed to assess the association of the two single nucleotide polymorphisms (SNPs) near P2 promoter (rs1884614 and rs2144908) of hepatocyte nuclear factor-4alpha (HNF4A) with insulin secretion index and type 2 diabetes in Thais.
|
17805472 |
2007 |
|
rs2144908
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequencies of the minor alleles were as follows: 19.2% in T2DM vs. 17.6% in controls for rs2144908; and 20.6% vs. 20.1% for rs4810424, respectively.
|
16523192 |
2006 |