Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2237895
rs2237895
0.900 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE KCNQ1 polymorphism at SNPs rs151290 and rs2237895 is strongly associated with CVD in this population, but presented no association with T2D. 28863213

2019

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE Three loci showed nominal POE, including the previously reported variants in KCNQ1, for type 2 diabetes in families from Botnia (rs2237895: p POE  = 0.037), which can be considered positive controls. 27155871

2016

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE The main anthropometric and biochemical parameters did not correlate with the rs2237892 or rs2237895 SNPs in the T2DM group (P > 0.05). 27323013

2016

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE Results showed that the T2D risk alleles of rs243021 located near BCL11A, rs10830963 in MTNR1B, and rs2237895 in KCNQ1 were related to a lower risk for abdominal obesity in T2D patients (rs243021: 0.92 (0.84, 1.00), P = 4.42 × 10-2; rs10830963: 0.92 (0.85, 1.00), P = 4.07 × 10-2; rs2237895: 0.89 (0.82, 0.98), P = 1.29 × 10-2). 26599349

2015

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE Variants in the KCNQ1 (rs2237895, p = 0.0012), HHEX (rs1111875, p = 0.0024 in Finns) and MTNR1B (rs10830963, p = 0.0039) loci showed the strongest association in patients with low GADA, supporting the hypothesis that the disease in these patients is more like type 2 diabetes. 24906951

2014

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE Genotype at the type 2 diabetes risk variant rs2237895 influenced methylation levels of regulatory sequence in fetal pancreas but without demonstrable effects on gene expression. 23139357

2013

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE We aimed to evaluate the effect of four common variants (rs2237892, rs2283228, rs2237895, and rs2237897) in KCNQ1 on susceptibility of type 2 diabetes (T2D) by performing a case-control study as well as a comprehensive meta-analysis. 23786590

2013

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE COL8A1 rs792837 (P=2.9 × 10(-9)), KCNQ1 rs2237892 (P=1.8 × 10(-18)) and rs2237895 (P=0.002), ALX4 rs729287 (Pc=7.5 × 10(-5)), and HNF1 rs4430796 (P=0.003) were significantly associated with T2DM, with similar effect sizes to those of Europeans. 24145053

2013

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE In conclusion, KCNQ1 rs2237892 and rs2237895 polymorphisms were found to be associated with the therapeutic efficacy of repaglinide in Chinese T2DM patients. 22414228

2012

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE This meta-analysis suggests that the rs2237892 and rs2237895 polymorphisms in KCNQ1 are associated with elevated type 2 diabetes susceptibility. 23133642

2012

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE Haplotype analysis further suggested that the T2D risk associated with KCNQ1 SNPs may be derived from 'G' allele of rs231362 and 'C' allele of rs2237895 and this appears to be mediated through β cell function. 21261977

2011

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE The haplotype TCA containing the allele of rs2237892 (T), rs2283228 (C) and rs2237895 (A) was highly protective against T2D (Second model; OR = 0.17, P = 3.7 × 10(-11)). 22016621

2011

dbSNP: rs2237895
rs2237895
C 0.900 GeneticVariation GWASDB We also confirmed that variants in KCNQ1 were associated with T2D risk, with the strongest signal at rs2237895 (P = 9.65x10(-10); OR = 1.29, 95% CI = 1.19-1.40). 20174558

2010

dbSNP: rs2237895
rs2237895
C 0.900 GeneticVariation GWASCAT We also confirmed that variants in KCNQ1 were associated with T2D risk, with the strongest signal at rs2237895 (P = 9.65x10(-10); OR = 1.29, 95% CI = 1.19-1.40). 20174558

2010

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE We also confirmed that variants in KCNQ1 were associated with T2D risk, with the strongest signal at rs2237895 (P = 9.65x10(-10); OR = 1.29, 95% CI = 1.19-1.40). 20174558

2010

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE The minor C-allele of rs2237895 of KCNQ1, which has a prevalence of about 42% among Caucasians was associated with reduced measures of insulin release following an oral glucose load suggesting that the increased risk of type 2 diabetes, previously reported for this variant, likely is mediated through an impaired beta cell function. 19516902

2009

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE Notably, the associations with type 2 diabetes were markedly attenuated after adjusting for HOMA-B (OR(rs2237892): 1.33 [1.05-1.68], P = 0.018; OR(rs2237895): 1.24 [1.00-1.54], P = 0.0524; OR(rs2237897): 1.22[0.98-1.53], P = 0.09). 19556355

2009

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE The C-allele of KCNQ1 rs2237895 was associated with increased risk of type 2 diabetes in both the Malmö Case-Control (odds ratio 1.23 [95% CI 1.12-1.34]; P = 5.6 x 10(-6)) and the prospective (1.14 [1.06-1.22]; P = 4.8 x 10(-4)) studies. 19584308

2009

dbSNP: rs2237895
rs2237895
0.900 GeneticVariation BEFREE Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 x 10(-9); OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 x 10(-13); OR = 1.41, 95% CI = 1.29-1.55). 18711366

2008