We found that the T allele of rs2476601 and the A allele of rs33996649within <i>PTPN22</i> gene, interaction between rs2476601 and T2DM were all associated with increased PTB risk.
To evaluate the impact of a functional variation in the PTPN22 gene in type 1 (T1D) and type 2 diabetes</span> (T2D), the PTPN22 C1858T single nucleotide polymorphism (SNP) was studied in the population of Estonian origin, including 170 T1D patients, 244 T2D patients and 230 controls.
Analysis for the C1858T polymorphism using the TaqMan assay was performed in 250 subjects with adult-onset autoimmune diabetes, divided into two subgroups with low (<or=32 arbitrary units) or high (>32 arbitrary units) GADA titers and 450 subjects with classic type 2 diabetes (from the Non Insulin Requiring Autoimmune Diabetes [NIRAD] Study cohort of 5,330 subjects with adult-onset diabetes) and in 558 subjects with juvenile-onset type 1 diabetes and 545 normoglycemic subjects.