rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM.
|
31299695 |
2019 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
T2D was significantly associated with promoter rs266729, rs17300539, rs1884613, rs2144908, and rs4810424, and the association of T2D risk were affected by study population, diagnostic criteria, and genotype methods.
|
30860284 |
2019 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sources of control populations were the cause of between-study heterogeneity; nonetheless, there was no publication bias among studies.The G allele of rs266729 in adiponectin gene increases the risk of T2DM through an additive genetic model with an effect of 1.13 (1.06, 1.19).
|
29381968 |
2017 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we found an effect modification of obesity on the association between the ADIPOQ rs266729 SNP and total cholesterol (P = 0.00068) only in obese participants after adjusting for age, gender, BMI, and T2D status.
|
27388775 |
2016 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Adiponectin gene polymorphism rs266729 is involved in the pathogenesis of T2DM.
|
26051417 |
2015 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.
|
24825737 |
2015 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant interaction was observed between two SNPs rs13306519 in LEPR and rs266729 in ADIPOQ for T2DM (P_int = 0.012, OR_int = 2.67) and hypertension (P_int = 0.0041, OR_int = 2.23).
|
24414038 |
2014 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Of the 8 variants, four SNPs namely, +276 G/T (rs1501299), -4522 C/T (rs822393), -11365 C/G (rs266729), and +712 G/A (rs3774261) were significantly associated with T2DM in our study population.
|
24055485 |
2013 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To derive a more precise estimation, we performed a meta-analysis to assess the association between five AdipoQ polymorphisms [-11426A > G (rs16861194), -11391G > A (rs17300539), -11377C > G (rs266729), +45T > G (rs2241766) and +276G > T (rs1501299)], and T2DM risk.
|
23653335 |
2013 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729</span> were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only.
|
22497971 |
2012 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, G vs C allele of -11377C>G (rs266729) might be a risk factor for type 2 diabetes.
|
21638131 |
2011 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs266729 C allele and the rare minor alleles of rs2241766 and rs2082940 were associated with an increased adjusted hazard ratio of developing T2DM.
|
21219602 |
2011 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis.
|
20580771 |
2010 |
rs266729
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the contrary, -11377C/G (rs266729) was associated with type 2 diabetes in the obese group only (OR=2.45, 95%CI: 1.13-5.31, P=0.02), and 59% risk of diabesity could be attributed to that.
|
19359061 |
2009 |