Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE To investigate the role of IRS1 locus on failure to oral antidiabetes drugs (OADs) we genotyped single-nucleotide polymorphisms (SNPs), rs2943641, rs7578326 (tagging all SNPs genome-wide associated with type 2 diabetes (T2D) and related traits at this locus) and rs1801278 (that is, the loss-of-function IRS1 G972R amino acid substitution) in 2662 patients with T2D. 28696414

2018

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE It also indicates that rs2943641 may be associated with type 2 diabetes risk in Caucasian. 26582067

2016

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE Participants with different genotypes of IRS1 rs2943641 exhibit differential benefit from high circulating 25(OH)D for the reduction of insulin resistance and T2D risk. 24255076

2014

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE In conclusion, both the (rs1801278 and rs2943641) polymorphisms are associated with T2DM in the Saudi population. 24493031

2014

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation GWASDB Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. 23300278

2013

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE A recent genome-wide association study identified rs2943641C>T as a susceptibility locus for type 2 diabetes mellitus (T2DM) in Caucasian patients. 22576021

2013

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE Our study was not able to demonstrate the association between rs2943641 near IRS1 and T2DM in a Chinese Han population. 22576021

2013

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE Our results indicate that IRS1 rs2943641 interacts with carbohydrate and fat intakes on incident T2D in a sex-specific fashion. 23221578

2013

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE Two IRS1 variants (rs7578326 and rs2943641) identified by genome-wide association studies as related to type 2 diabetes were tested for their associations with IR and related traits and interaction with diet in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 820) and the Boston Puerto Rican Health Study (BPRHS) (n = 844). 23596181

2013

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE We tested 1) four SNPs previously shown to be associated with IR (rs2972146, rs2943650), T2D (rs2943641) or CAD (rs2943634) and 2) any SNP at 2q36.3-IRS1, for association with subclinical atherosclerosis traits, adjusting for atherosclerosis risk factors. 23659870

2013

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation GWASDB Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. 21647700

2011

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE SNP rs2943641 near the insulin receptor substrate 1 (IRS1) gene has been found to be associated with type 2 diabetes (T2D) and insulin-resistance in genome-wide association studies. 21353221

2011

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, (P = 0.0034, OR = 1.15 95% confidence interval; 1.05-1.26) and 3 SNPs, rs10930963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples (P<0.05). 22046406

2011

dbSNP: rs2943641
rs2943641
C 0.900 GeneticVariation GWASCAT Unlike previously reported T2D risk loci, which predominantly associate with impaired beta cell function, the C allele of rs2943641 was associated with insulin resistance and hyperinsulinemia in 14,358 French, Danish and Finnish participants from population-based cohorts; this allele was also associated with reduced basal levels of IRS1 protein and decreased insulin induction of IRS1-associated phosphatidylinositol-3-OH kinase activity in human skeletal muscle biopsies. 19734900

2009

dbSNP: rs2943641
rs2943641
0.900 GeneticVariation BEFREE We then selected the 28 best hits for replication in 7,698 Danish subjects and identified 4 SNPs showing strong association with T2D, one of which (rs2943641, P = 9.3 x 10(-12), OR = 1.19) was located adjacent to the insulin receptor substrate 1 gene (IRS1). 19734900

2009