Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.090 | GeneticVariation | BEFREE | Methylenetetrahydrofolate Reductase (MTHFR) (C677T and A1298C) Polymorphisms and Vascular Complications in Patients with Type 2 Diabetes. | 28341195 | 2017 |
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0.090 | GeneticVariation | BEFREE | These results show an evident association between the MTHFR C677T polymorphism and T2DM in Moroccan patients but no significant association with the MTHFR A1298C polymorphism. | 22103601 | 2012 |
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0.090 | GeneticVariation | BEFREE | Our study for the first time demonstrated a synergistic effect between ACE I/D with either MTHFR C677T or A1298C polymorphism on the increased risk of DN among patients with T2DM. | 21942443 | 2012 |
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0.090 | GeneticVariation | BEFREE | MTHFR C677T and A1298C genotypes were analyzed in 56 T2DM and 62 healthy subjects by PCR-RFLP. | 22008727 | 2011 |
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0.090 | GeneticVariation | BEFREE | We investigated the association of C677T and A1298C MTHFR gene variants and altered homocysteine concentrations in Lebanese and Bahraini type 2 diabetes (T2DM) DN patients. | 20524928 | 2010 |
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0.090 | GeneticVariation | BEFREE | Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus. | 20800057 | 2010 |
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0.090 | GeneticVariation | BEFREE | MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients. | 16828193 | 2007 |
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0.090 | GeneticVariation | BEFREE | This study aimed to investigate the influence of the C677T and A1298C polymorphisms of the MTHFR gene on the development of diabetic nephropathy in Caucasian patients with type 2 diabetes. | 12897091 | 2003 |
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0.090 | GeneticVariation | BEFREE | The frequency of two MTHFR mutations, a recently described mutation in the human MTHFR gene A1298C and C677T, whose association with DN is already known, was determined in an Israeli Jewish population with type 2 diabetes mellitus (DM). | 11015479 | 2000 |