Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Association of β3-adrenergic receptor rs4994 polymorphisms with the risk of type 2 diabetes: A systematic review and meta-analysis. 28521197

2017

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE UCP1 -3826A/G and ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) Caucasian-Brazilian patients. 24138564

2014

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE This study was undertaken to analyse a single nucleotide polymorphism Trp64Arg (C↔T) in the ADRB3 gene and elucidate its effects on type 2 diabetes and its associated risk factors. 23968135

2013

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population. 22391941

2012

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE The β3-adrenoceptor (ADRB3) gene Trp64Arg polymorphism has been shown to be associated with obesity as well as type 2 diabetes and cardiovascular disease. 22609474

2012

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03). 21992420

2011

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. 20536507

2010

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE In contrast, the non-synonymous ADRB3 rs4994 polymorphism is associated with T2D and MS. 20503258

2010

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Furthermore, the association of Trp64Arg with type 2 diabetes was examined in a meta-analysis. 18249022

2008

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus. 18335327

2008

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Effect of the combination of the variants -75G/A APOA1 and Trp64Arg ADRB3 on the risk of type 2 diabetes (DM2). 17727676

2008

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta3-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus. 17852419

2007

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Thus, heterozygosity for the Trp64Arg variant is unlikely to increase the risk of obesity, insulin resistance or type 2 diabetes. 16634992

2006

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE We studied possible relations between GDM and both insulin receptor substrate 1 (IRS-1) (Gly972Arg) and beta3-adrenergic receptor (ADRB3 Trp64Arg, beta3-AR) gene mutations, considered potential modifying factors in the etiology of type 2 diabetes mellitus. 17046546

2006

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE The Trp64Arg polymorphism in the beta3AR gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes; little is known about its possible association with cancer. 15743038

2004

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE The beta(3)-adrenergic receptor gene (BAR-3) allelic variant (Trp64Arg and Arg64Arg) is correlated with obesity or non-insulin-dependent diabetes mellitus. 12943691

2003

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro. 12965109

2003

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men. 11699048

2001

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample. 11522702

2001

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Our results suggest that the Trp64Arg mutation is not a major determinant of metabolic disorders (type 2 diabetes, obesity) and chronic complications of type 2 diabetes in a Dutch population. 11213599

2001

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes. 11380082

2001

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus. 10981554

2000

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE The Trp64Arg beta3AR variant is associated in some, but not all, studies with an earlier onset of Type 2 diabetes mellitus and features of the insulin resistance syndrome. 10441039

1999

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE The Trp64Arg mutation is not a major determinant of Type 2 diabetes and its microangiopathic complications. 10197086

1998

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort. 9709965

1998