Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE The finding revealed the all measured inheritance models of rs1111875G/A and of rs5015480C/T variants dramatically increase the risk of T2D while another polymorphism (rs7923837A/G) was not associated with risk/protective role in T2D. 31237015

2019

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM. 31299695

2019

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (<i>TCF7L2</i> rs7901695, <i>FTO</i> rs8050136, <i>HHEX</i> rs5015480, <i>SLC30A8</i> rs13266634 and <i>IGF2BP2</i> rs4402960) were observed in this study population. 28067832

2017

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation GWASDB Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. 23300278

2013

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE Single nucleotide polymorphisms in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation. 23298195

2013

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160

2012

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012

dbSNP: rs5015480
rs5015480
C 0.900 GeneticVariation GWASCAT Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 22693455

2012

dbSNP: rs5015480
rs5015480
C 0.900 GeneticVariation GWASDB Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 22693455

2012

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609. 22377712

2012

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE Our results provide clarification to the significant association of rs1111875, rs5015480 and rs7923837 in HHEX gene with type 2 diabetes. 23166797

2012

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation GWASDB Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. 22158537

2011

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE Further analysis revealed that the sequence variant (rs5015480) near HHEX and two SNPs (rs7756992 and rs9465871) in CDKAL1 were associated with the susceptibility of T2DM in females (P<0.005), but not in males (P>0.005). 21368910

2011

dbSNP: rs5015480
rs5015480
C 0.900 GeneticVariation GWASDB Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. 20581827

2010

dbSNP: rs5015480
rs5015480
C 0.900 GeneticVariation GWASCAT Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. 20581827

2010

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index. 20509872

2010

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied. 20550665

2010

dbSNP: rs5015480
rs5015480
C 0.900 GeneticVariation GWASDB Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. 18372903

2008

dbSNP: rs5015480
rs5015480
C 0.900 GeneticVariation GWASCAT Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. 18372903

2008

dbSNP: rs5015480
rs5015480
0.900 GeneticVariation BEFREE The SNPs rs5015480 [odds ratio (OR) = 1.46 (95% CI 1.20-1.77), p = 2.0 x 10(-4)], rs7923837 [OR = 1.40 (95% CI 1.17-1.68), p = 2.0 x 10(-4)] and rs1111875 [OR = 1.30 (95% CI 1.11-1.52), p = 0.0013] in HHEX were significantly associated with type 2 diabetes with the same direction as previously reported. 17928989

2007