| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.100 | GeneticVariation | BEFREE | Therefore, Q192R polymorphism was more correlated with type 2 diabetes mellitus. | 31102685 | 2019 |
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0.100 | GeneticVariation | BEFREE | PON1 (Q192R and L55M) polymorphisms may play a crucial role in pathogenesis and susceptibility of insulin resistance thus leads to the development of type 2 diabetes in South Indian population. | 29409844 | 2018 |
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0.100 | GeneticVariation | BEFREE | Sex should be considered a confounding variable in association studies on the variants PON1-Q192R and PON2-A148G in T2D. | 29782842 | 2018 |
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0.100 | GeneticVariation | BEFREE | As for the PON1 Q192R polymorphism, the 192R allele was a susceptible factor of T2DM in the South or East Asian population (OR > 1, P < 0.05) but represented a protective factor of T2DM in European population (OR = 0.66, 95% CI = 0.45-0.98) under a heterozygous genetic model. | 29314660 | 2018 |
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0.100 | GeneticVariation | BEFREE | Our data suggest that the variant PON1-Q192R and PON1 activity, particularly PON-aryl, influenced the antioxidant status in T2D. | 27022137 | 2016 |
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0.100 | GeneticVariation | BEFREE | This study will give an insight about the association of two selected candidate gene polymorphisms; paraoxonase1 (PON1) Q192R and apolipoprotein A5 (APOA5) -1131T>C were assessed in a cohort of South Indian patients having CAD with and without T2DM. | 21438666 | 2011 |
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0.100 | GeneticVariation | BEFREE | We investigated whether the human serum paraoxonase (PON1) Q/R 192 and M/L 55 polymorphisms are associated with the complications of the type 2 diabetes (T2D). | 21223956 | 2011 |
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0.100 | GeneticVariation | BEFREE | QR, RR (Q192R) and GC, CC (-909G/C) genotypes and L-C-A-R-G, L-T-A-R-G, L-T-G-Q-C haplotypes showed significant association with type 2 diabetes. | 21803130 | 2011 |
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0.100 | GeneticVariation | BEFREE | Serum Pon1 activities in both DM and non-DM patients on HD were regulated by Pon1 Q192R polymorphism: RR > QR > QQ. | 14579940 | 2003 |
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0.100 | GeneticVariation | BEFREE | The difference in allele frequency for the PON(1) Q/R 192 gene polymorphism may be the cause of the low paraoxonase activity observed in type 2 diabetes mellitus. | 12442067 | 2002 |
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0.100 | GeneticVariation | BEFREE | Paraoxonase 1 192 Gln/Arg gene polymorphism and cerebrovascular disease: interaction with type 2 diabetes. | 11409295 | 2001 |
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0.100 | GeneticVariation | BEFREE | It has been hypothesized an A/B (Gln 192-->Arg) polymorphism of PON may be involved in the pathogenesis of CHD, especially among subjects with non-insulin-dependent diabetes mellitus (NIDDM). | 8960946 | 1996 |