|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Different statistical models revealed that all the dominant models were found associated in between alleles for disease risk (p < 0.001) while no association of PC-1 rs1044498 (K121Q) polymorphism was found with insulin-resistant parameters in T2DM cases.
|
31250990 |
2019 |
|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, association of K121Q (rs1044498) polymorphism of the ENPP1 gene with T2DM and bone disorders is evaluated.
|
28942038 |
2017 |
|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study indicates that the ENPP1 rs1044498 SNP is associated with T2D, waist circumference, and fasting glucose in Taiwanese subjects.
|
27238374 |
2016 |
|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population.
|
22391941 |
2012 |
|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Allelic and genotypic analyses showed significant main effects of ENPP1 rs1044498 (P = 0.000005 and 0.00007, respectively) on the risk of T2D after Bonferroni correction (P < 0.05/2 = 0.025).
|
23111648 |
2012 |
|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For this reason, the present study looked at the contribution of ENNP1 (rs1044498), IGF2BP2 (rs1470579), KCNJ11 (rs5219), MLXIPL (rs7800944), PPARγ (rs1801282), SLC30A8 (rs13266634) and TCF7L2 (rs7903146) SNPs to the risk of T2DM in Lebanese and Tunisian Arabs.
|
22749234 |
2012 |
|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The K121Q (rs1044498) single nucleotide polymorphism (SNP) in the ENPP1 gene has shown association with insulin resistance and type 2 diabetes in various ethnic populations.
|
20091022 |
2010 |
|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The K121Q (lysine to glutamine substitution at amino acid 121, encoded by single-nucleotide polymorphism rs1044498) variant of the ectonucleotide pyrophosphatase/phosphodiesterase gene (ENPP1) has been associated with insulin resistance and related vascular complications in patients with type 2 diabetes (T2D) in many, although not all, studies.
|
18950909 |
2009 |
|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Ectoenzyme nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling, and a recent meta-analysis reported a nominal association between the Q allele in the K121Q (rs1044498) single nucleotide polymorphism in its gene ENPP1 and type 2 diabetes.
|
19017751 |
2009 |
|
rs1044498
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CAPN10 (rs3792267) was marginally associated with T2D with OR=1.5 (p=0.08) when considering the model GG vs. AG/AA with risk allele G. ENPP1 (rs1044498) was not associated with T2D.
|
19643578 |
2009 |
|
rs55725924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the ENPP1 polymorphism rs7754586 may implicate in the pathogenesis of T2D in men, while polymorphism rs55725924 may be involved in diastolic blood pressure and cholesterol of male T2D patients.
|
28951309 |
2017 |
|
rs7754586
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the ENPP1 polymorphism rs7754586 may implicate in the pathogenesis of T2D in men, while polymorphism rs55725924 may be involved in diastolic blood pressure and cholesterol of male T2D patients.
|
28951309 |
2017 |
|
rs2021966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes associations in PPARG, KCNJ11, and SLC2A2; identified significant SNPs in genes with previously reported associations (ENPP1 [rs2021966, P = 0.00026] and NRF1 [rs1882095, P = 0.00096]); and implicated novel genes, including RAPGEF1 (rs4740283, P = 0.00013) and TP53 (rs1042522, Arg72Pro, P = 0.00086), in type 2 diabetes susceptibility.
|
18678618 |
2008 |
|
rs943003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Weaker associations were detected between the SNPs rs1541276 in the MC5R, rs1926065 in the MC3R genes and obesity (P = 0.04 and P = 0.03, respectively), and between SNPs rs2236700 in the MC5R, rs2118404 in the POMC, rs943003 in the ENPP1 genes and type 2 diabetes (P = 0.03, P = 0.02 and P = 0.02, respectively); these associations did not, however, remain significant after correction for multiple testing.
|
18551113 |
2008 |
|
rs1799774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These SNPs were rs7754561 with type 2 diabetes (odds ratio for the G-allele, 0.85 [95% CI 0.78-0.92], P = 0.00003) and rs1799774 with BMI (homozygotes of the delT-allele, 0.6 [0.42-0.88], P = 0.007).
|
17065359 |
2006 |
|
rs7754561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These SNPs were rs7754561 with type 2 diabetes (odds ratio for the G-allele, 0.85 [95% CI 0.78-0.92], P = 0.00003) and rs1799774 with BMI (homozygotes of the delT-allele, 0.6 [0.42-0.88], P = 0.007).
|
17065359 |
2006 |
|
rs997509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we found a new SNP, rs99</span>7509, in intron 1 that is strongly associated with risk of type 2 diabetes in obese individuals.
|
16936213 |
2006 |