rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The risk of T2DM in individuals with GG genotype for Gly1057Asp in IRS2 gene was 1.42 times higher than that with AA genotype (OR = 1.422; 95% CI = 1.037-1.949; P = 0.029).
|
28049237 |
2017 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that D allele of G1057D polymorphism have a significant effect on reduced risk of T2DM, and obesity is a modifier of this association.
|
25959789 |
2015 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings revealed that IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group.
|
22994406 |
2012 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G1057D polymorphism in the insulin receptor substrate-2 (IRS-2) gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes.
|
20184486 |
2010 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results strongly argue against a major role of the Gly1057Asp IRS-2 polymorphism in the pathogenesis of type 2 diabetes in Djerbian subjects.
|
19332049 |
2009 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G1057D polymorphism of IRS-2 gene and its relationship with obesity in conferring susceptibility to type 2 diabetes in Asian Indians.
|
16652127 |
2007 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A commonly occurring nucleotide polymorphism of the insulin-receptor substrate 2 (IRS-2) gene at amino acid 1057 from Glycine to Asparaginic acid (G1057D) was recently shown to be a determinant of insulin sensitivity in both glucose-tolerant individuals and those with type 2 diabetes.
|
15811564 |
2005 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate whether common polymorphisms in the genes regulating the early insulin signalling pathway (insulin; A-23T, insulin-like growth factor 1 receptor [IGF-1R]; GAG1013GAA, plasma cell membrane glycoprotein 1 [PC-1]; K121Q, insulin receptor substrate [IRS-1]; G972R, insulin receptor substrate 2 [IRS-2]; G1057D and phosphatidylinositol 3-kinase p85 alpha [PI3K]; M326I) affect the weight change and development of Type 2 diabetes in the Finnish Diabetes Prevention Study.
|
15127203 |
2004 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The effect of the Gly1057Asp mutation on type 2 diabetes and obesity was tested in a large cohort of Pima Indians (n = 998).
|
12765968 |
2003 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the significance of Gly1057Asp and Leu647Val insulin receptor substrate (IRS)-2 polymorphisms in two Italian cohorts comprising 186 glucose-tolerant subjects and 240 subjects with type 2 diabetes from the Lazio region (i.e. representative of central Italy), and 123 glucose-tolerant subjects from the Sicily region (i.e. representative of south Italy).
|
12519871 |
2003 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, IRS-1 (Gly(972)Arg) and IRS-2 (Gly(1057)Asp), influence susceptibility to type 2 diabetes.
|
12213887 |
2002 |
rs1805097
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data provide evidence for a strong association between type 2 diabetes and the G1057D common genetic variant of IRS-2, which appears to be protective against type 2 diabetes in a codominant fashion.
|
11030756 |
2000 |
rs137852740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the significance of Gly1057Asp and Leu647Val insulin receptor substrate (IRS)-2 polymorphisms in two Italian cohorts comprising 186 glucose-tolerant subjects and 240 subjects with type 2 diabetes from the Lazio region (i.e. representative of central Italy), and 123 glucose-tolerant subjects from the Sicily region (i.e. representative of south Italy).
|
12519871 |
2003 |