Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE We conclude that neither the M235T nor the T174M polymorphism in the angiotensinogen gene contributes to genetic susceptibility to diabetic nephropathy in white IDDM patients, whereas the TT genotype of the M235T is associated with elevated blood pressure in patients with diabetic nephropathy. 8593944

1996

dbSNP: rs4762
rs4762
AGT
0.050 GeneticVariation BEFREE We conclude that neither the M235T nor the T174M polymorphism in the angiotensinogen gene contributes to genetic susceptibility to diabetic nephropathy in white IDDM patients, whereas the TT genotype of the M235T is associated with elevated blood pressure in patients with diabetic nephropathy. 8593944

1996

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE These results suggested that ACE I/D polymorphism, but not AGN M235T polymorphism, is a possible genetic risk factor for diabetic nephropathy in Japanese NIDDM patients. 8596493

1996

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE These results suggested that ACE I/D polymorphism, but not AGN M235T polymorphism, is a possible genetic risk factor for diabetic nephropathy in Japanese NIDDM patients. 8596493

1996

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. 8877296

1996

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. 8877296

1996

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE The data argue against a role of the angiotensinogen gene M235T polymorphism in the manifestation of diabetic nephropathy or hypertension in diabetic patients. 8918618

1996

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy. 9049480

1997

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy. 9049480

1997

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE In conclusion, results obtained in our family-based study support a role of the angiotensinogen gene M235T polymorphism, and specifically the T allele, in the development of diabetic nephropathy in IDDM. 9461232

1998

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE DNA polymorphism M235T in the angiotensinogen gene, which is associated with higher expression of this gene, contributes to the risk of diabetic nephropathy in NIDDM men but not in women. 9535411

1998

dbSNP: rs5443
rs5443
0.020 GeneticVariation BEFREE In conclusion we can find no evidence for the C825T polymorphism of the beta3 G-protein subunit as a major gene in the susceptibility to diabetic nephropathy in Type I diabetes. 9833937

1998

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE The data do not support a role of ACE (DD/II) or Atg M235T polymorphism in the development of diabetic nephropathy in Chinese patients with type II diabetes, and no synergistic effect was found between them. 10352194

1999

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE The data do not support a role of ACE (DD/II) or Atg M235T polymorphism in the development of diabetic nephropathy in Chinese patients with type II diabetes, and no synergistic effect was found between them. 10352194

1999

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE Therefore, we investigated the interaction between long-term glycaemic control and three polymorphisms in the genes coding for AGTR1 (A1166-->C), angiotensin converting enzyme (ACE/ID) and angiotensinogen (M235T) on risk of developing diabetic nephropathy. 10907125

2000

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE Therefore, we investigated the interaction between long-term glycaemic control and three polymorphisms in the genes coding for AGTR1 (A1166-->C), angiotensin converting enzyme (ACE/ID) and angiotensinogen (M235T) on risk of developing diabetic nephropathy. 10907125

2000

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Folate supplementation in diabetic patients with the C677T mutation and low-normal serum folate may prevent the onset or retard the progression of DN. 11015479

2000

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients. 11015479

2000

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE A substitution (M235T) polymorphism in angiotensinogen (AGT) may interact with ACE I/D polymorphism for the risk of diabetic nephropathy, but their prognostic values have to be established by follow-up studies. 11181802

2001

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE A substitution (M235T) polymorphism in angiotensinogen (AGT) may interact with ACE I/D polymorphism for the risk of diabetic nephropathy, but their prognostic values have to be established by follow-up studies. 11181802

2001

dbSNP: rs1799945
rs1799945
0.010 GeneticVariation BEFREE We performed an association study to assess the role of the C282Y and H63D mutations in the HFE gene as a risk factor for type 2 diabetes and diabetic nephropathy. 11423500

2001

dbSNP: rs1800562
rs1800562
0.010 GeneticVariation BEFREE We performed an association study to assess the role of the C282Y and H63D mutations in the HFE gene as a risk factor for type 2 diabetes and diabetic nephropathy. 11423500

2001

dbSNP: rs11538209
rs11538209
ALB
0.010 GeneticVariation BEFREE Our results suggest that TGF-beta1 T29C polymorphism is not associated with the progression of diabetic nephropathy. 11576951

2001

dbSNP: rs1800470
rs1800470
0.010 GeneticVariation BEFREE Our results suggest that TGF-beta1 T29C polymorphism is not associated with the progression of diabetic nephropathy. 11576951

2001

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE AGT gene M235T polymorphism is associated with diabetic nephropathy in NIDDM. 11717948

1999