Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10255208
rs10255208
0.010 GeneticVariation BEFREE The rs741301-G allele and the rs10255208-GG genotype, gene-environment interaction between rs741301 and alcohol drinking were all associated with increased DN risk. 31798690

2019

dbSNP: rs1345365
rs1345365
0.010 GeneticVariation BEFREE We also found that the others SNPs-rs1345365 and rs7782979 were not significantly associated with susceptibility to DN. 31798690

2019

dbSNP: rs17576
rs17576
0.010 GeneticVariation BEFREE MMP-9 (Gln279Arg) AA-genotype (OR 0.17 [0.04-0.62, p = 0.008]) and the time elapsed since diagnosis of T2D without onset of proteinuria (OR 0.87 [0.79-0.97, p = 0.008]) were found to be independently associated with reduced risk of susceptibility to DN. 30557881

2019

dbSNP: rs17592236
rs17592236
0.010 GeneticVariation BEFREE FOXO1 gene rs17446614 SNP, and the A-C haplotype of rs17446614 and rs17592236 polymorphisms were risk factors for the development of DN. 30987438

2019

dbSNP: rs1800775
rs1800775
0.010 GeneticVariation BEFREE In addition, the A-allele of rs4783961 was significantly associated with a reduced T2D risk (odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71‒0.96)), and the A-allele of rs1800775 was significantly related to a lowered DKD risk (OR, 0.78; 95% CI, 0.64‒0.96). 31597401

2019

dbSNP: rs1800797
rs1800797
0.010 GeneticVariation BEFREE This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN. 31451183

2019

dbSNP: rs2069837
rs2069837
0.010 GeneticVariation BEFREE This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN. 31451183

2019

dbSNP: rs2069840
rs2069840
0.010 GeneticVariation BEFREE This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN. 31451183

2019

dbSNP: rs2281999
rs2281999
0.010 GeneticVariation BEFREE RESULTS There were no significant differences in the distribution of allele or genotype frequencies in the five UNC13B SNP markers (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999) between the DKD group and control group of patients with T2DM. 31713534

2019

dbSNP: rs2966449
rs2966449
0.010 GeneticVariation BEFREE The association of rs2966449 with DKD was also found in the populations older than 70 years, male, not smoking, not drinking, and with duration for T2DM over 20 years. 31396261

2019

dbSNP: rs34713741
rs34713741
0.010 GeneticVariation BEFREE Comparing three groups, the results were the following: (a) There was a significant difference in the genotype and allele distribution of rs34713741 between DN group and HC group and between T2DM group and DN group; For this gene locus, the risk of diabetic nephropathy in healthy individuals with T allele was 0.6 times higher than that in individuals with GG genotype (OR = 0.60, 95% CI: 0.46 ~ 0.77). 31265177

2019

dbSNP: rs3765156
rs3765156
0.010 GeneticVariation BEFREE The top significant SNPs from the discovery samples were selected for replication in the independent cohort. rs3765156 in PIK3C2B was significantly associated with DN in the replication cohort after multiple test. 30883692

2019

dbSNP: rs4783961
rs4783961
0.010 GeneticVariation BEFREE In addition, the A-allele of rs4783961 was significantly associated with a reduced T2D risk (odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71‒0.96)), and the A-allele of rs1800775 was significantly related to a lowered DKD risk (OR, 0.78; 95% CI, 0.64‒0.96). 31597401

2019

dbSNP: rs499765
rs499765
0.010 GeneticVariation BEFREE However, a significant association with estimated glomerular filtration rate (eGFR) was detected: in the non-DKD group, rs838136 was significantly associated with eGFR under an additive model (<i>β</i> = 0.013 ± 0.006, <i>P</i> = 0.0295, <i>β</i> was calculated for log<sub>10</sub>eGFR) as well as a recessive model (<i>P</i> = 0.0385) and rs499765 was associated with eGFR under a dominant model (<i>P</i> = 0.0411) and in the DKD group, rs499765 showed a trend toward association with eGFR under an additive model (<i>β</i> = -0.022 ± 0.012, <i>P</i> = 0.0820, <i>β</i> was calculated for log<sub>10</sub>eGFR) and showed a significant association with eGFR under a dominant model (<i>P</i> = 0.0182). 31205953

2019

dbSNP: rs55703767
rs55703767
0.010 GeneticVariation BEFREE The rs55703767 minor allele (Asp326Tyr) is protective against several definitions of diabetic kidney disease, including albuminuria and ESKD, and demonstrated a significant association with GBM width; protective allele carriers had thinner GBM before any signs of kidney disease, and its effect was dependent on glycemia. 31537649

2019

dbSNP: rs6704078
rs6704078
0.010 GeneticVariation BEFREE In addition, patients with the T allele of rs6704078 had higher STB (13.2 [10.4-17.9] μmol/L versus 11.8 (9.4-14.8) μmol/L; p < 0.001) and similar risks of DR or DKD to those without the T allele. 31427625

2019

dbSNP: rs762285755
rs762285755
0.010 GeneticVariation BEFREE MMP-9 (Gln279Arg) AA-genotype (OR 0.17 [0.04-0.62, p = 0.008]) and the time elapsed since diagnosis of T2D without onset of proteinuria (OR 0.87 [0.79-0.97, p = 0.008]) were found to be independently associated with reduced risk of susceptibility to DN. 30557881

2019

dbSNP: rs7782979
rs7782979
0.010 GeneticVariation BEFREE We also found that the others SNPs-rs1345365 and rs7782979 were not significantly associated with susceptibility to DN. 31798690

2019

dbSNP: rs838136
rs838136
0.010 GeneticVariation BEFREE However, a significant association with estimated glomerular filtration rate (eGFR) was detected: in the non-DKD group, rs838136 was significantly associated with eGFR under an additive model (<i>β</i> = 0.013 ± 0.006, <i>P</i> = 0.0295, <i>β</i> was calculated for log<sub>10</sub>eGFR) as well as a recessive model (<i>P</i> = 0.0385) and rs499765 was associated with eGFR under a dominant model (<i>P</i> = 0.0411) and in the DKD group, rs499765 showed a trend toward association with eGFR under an additive model (<i>β</i> = -0.022 ± 0.012, <i>P</i> = 0.0820, <i>β</i> was calculated for log<sub>10</sub>eGFR) and showed a significant association with eGFR under a dominant model (<i>P</i> = 0.0182). 31205953

2019

dbSNP: rs852426
rs852426
0.010 GeneticVariation BEFREE The association of rs852426 with DKD sti</span>ll remained statistically significant after Bonferroni correction and particularly significant in the population older than 70 years rather than the 70 years or younger (<i>P</i> = 0.047 for heterogeneity test). 31396261

2019

dbSNP: rs11651270
rs11651270
0.010 GeneticVariation BEFREE NLRP1 rs2670660 and rs11651270 polymorphisms were significantly associated with a decrease risk to develop DKD (p<sub>adj</sub><0.01), and rs11651270 also with a lower risk of new renal events during follow-up (p<sub>adj</sub>=0.01). 29031829

2018

dbSNP: rs140407862
rs140407862
0.010 GeneticVariation BEFREE Immunofluorescence staining of COL4<i>α</i>3 was performed in kidney specimens of patients with DKD with or without R408H and M1209I of <i>COL4A3</i> variants. 30012629

2018

dbSNP: rs1695
rs1695
0.010 GeneticVariation BEFREE The purpose of this case-control study was to investigate the possible role of GSTM1 and GSTT1 deletion polymorphisms, and Single Nucleotide Polymorphism (SNP), GSTP1 313 A > G (Ile105Val), in DN susceptibility. 29981844

2018

dbSNP: rs1800629
rs1800629
TNF
0.010 GeneticVariation BEFREE The present study was designed to investigate the association of TNF-α [-308G/A, (rs1800629)] single nucleotide polymorphism (SNP) on the susceptibility to DN subjects and to correlate it with the plasma levels of TNF-α along with circulatory TNF-α receptor super family cytokines (sTNFR-1 and sTNFR-2). 29042282

2018

dbSNP: rs2070744
rs2070744
0.010 GeneticVariation BEFREE As for vascular complications in DM, significant associations with the susceptibility to diabetic nephropathy were detected for the rs1799983 and rs2070744 polymorphisms. 30140993

2018