|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The current meta-analysis suggested that MTHFR C677T polymorphism might influence DN risk, but not for DM in the Chinese population.
|
23822721 |
2013 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We observed a significant association of MTHFR C677T with development of diabetic nephropathy in type 2 diabetics.
|
23846111 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects.
|
24603156 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the association of functional single nucleotide polymorphisms (SNPs) of the endothelial nitric oxide synthase gene (eNOS) gene (T-786C, G894T) and one variable number tandem repeat polymorphism (aa 27VNTR bb) with reno-protective response to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) therapy in North Indian type 2 diabetic mellitus (T2DM) subjects with cases having diabetic nephropathy (DN) and controls without DN.
|
23260854 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a link between eNOS Glu298Asp gene polymorphism and DN risk was not found in overall populations, Asians, Caucasians, and Brazil population.
|
23113598 |
2013 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study for the first time demonstrated a synergistic effect between ACE I/D with either MTHFR C677T or A1298C polymorphism on the increased risk of DN among patients with T2DM.
|
21942443 |
2012 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C677T polymorphism in MTHFR gene may be a risk factor for DN, but not for DM, in a Chinese population.
|
22209973 |
2012 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An updated meta-analysis of methylenetetrahydrofolate reductase gene 677C/T polymorphism with diabetic nephropathy and diabetic retinopathy.
|
22056717 |
2012 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients.
|
22554825 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the association of three polymorphisms of the eNOS gene (894G>T, -786T>C, and 27-bp-VNTR) with the risk of DN among type 2 diabetic patients.
|
22313046 |
2012 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients.
|
22554825 |
2012 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study for the first time demonstrated a synergistic effect between ACE I/D with either MTHFR C677T or A1298C polymorphism on the increased risk of DN among patients with T2DM.
|
21942443 |
2012 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A number of studies have evaluated the association between the functional polymorphisms, AGT M235T and AGTR1 A1166C, and DN risk with conflicting results.
|
21607620 |
2012 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This case-control study assessed the association of MTHFR C677T mutation in T2DM and DN cases.
|
21186995 |
2011 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study has investigated the role of endothelial nitric oxide (eNOS) G894T polymorphism and its interaction with methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C variants on the predisposition to diabetic nephropathy and its progression.
|
21380725 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The evidence accumulated suggested that 4b/a and G894T polymorphisms in the eNOS gene were associated with susceptibility to DN in Asian populations, but not in Caucasian populations.
|
21084433 |
2011 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study has investigated the role of endothelial nitric oxide (eNOS) G894T polymorphism and its interaction with methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C variants on the predisposition to diabetic nephropathy and its progression.
|
21380725 |
2011 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study has shown that AGT M235T TT genotype and APO E ε 2/3 genotype may be linked to a risk for DN among Turkish population.
|
21500980 |
2011 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three-locus AGT haplotype analysis (A-6G/T174M/M235T) identified DN-protective (ATM, AMM, GTM) and DN-susceptible (GTM, ATT, GMT and AMT) haplotypes, and demonstrated enrichment of GTT haplotype in macroalbuminuric compared to microalbuminuric or normoalbuminuric patients.
|
21421655 |
2011 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The contribution of C677T single nucleotide polymorphism to increased risk of DN (presumably by increasing homocysteine concentrations) must be evaluated in the context of the ethnic background.
|
20524928 |
2010 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To find whether polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C are risk factors for diabetic nephropathy (DN) among type 2 diabetes mellitus (T2DM) patients from Western Iran.
|
20800057 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We performed a meta-analysis of 28 association studies focusing on three polymorphisms in the NOS3 gene (G894T (Glu289Asp), 4b/a, and T-786C) and the risk of DN published before July 2009, covering a total of 10,364 subjects.
|
20049477 |
2010 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A1298C allele and genotype distribution were comparable between DN and DWN patients in both communities.
|
20524928 |
2010 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To find whether polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C are risk factors for diabetic nephropathy (DN) among type 2 diabetes mellitus (T2DM) patients from Western Iran.
|
20800057 |
2010 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was a significant correlation of plasma homocysteine level with microalbuminuria (r = 0.54; P = 0.031) in the patients with diabetic nephropathy who had C677T polymorphism.
|
19598005 |
2009 |