Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE As for vascular complications in DM, significant associations with the susceptibility to diabetic nephropathy were detected for the rs1799983 and rs2070744 polymorphisms. 30140993

2018

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In this study, a case-control study was carried out to investigate the effects of 7 SNPs in ACE gene and 2 SNPs in eNOS gene in the development of DN in Northern China.7 SNPs including A240T, A2350G, A5466C, A2215G, T3892C, C1237T and C3409T of ACE gene and 2 SNPs (G894T and T786C) of eNOS gene were genotyped by polymerase chain reaction restriction fragment length polymorphism method. 25227524

2015

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE For eNOS-G894T, there was an association between T allele and DN risk in the global, Asian and African population in DN/T2DM group. 26489520

2015

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE G894T polymorphism was associated with DN only in allele contrast and in co-dominance model. 24433471

2014

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE However, a link between eNOS Glu298Asp gene polymorphism and DN risk was not found in overall populations, Asians, Caucasians, and Brazil population. 23113598

2013

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE To investigate the association of functional single nucleotide polymorphisms (SNPs) of the endothelial nitric oxide synthase gene (eNOS) gene (T-786C, G894T) and one variable number tandem repeat polymorphism (aa 27VNTR bb) with reno-protective response to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) therapy in North Indian type 2 diabetic mellitus (T2DM) subjects with cases having diabetic nephropathy (DN) and controls without DN. 23260854

2013

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. 24603156

2013

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The aim of this study was to evaluate the association of three polymorphisms of the eNOS gene (894G>T, -786T>C, and 27-bp-VNTR) with the risk of DN among type 2 diabetic patients. 22313046

2012

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The evidence accumulated suggested that 4b/a and G894T polymorphisms in the eNOS gene were associated with susceptibility to DN in Asian populations, but not in Caucasian populations. 21084433

2011

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE We performed a meta-analysis of 28 association studies focusing on three polymorphisms in the NOS3 gene (G894T (Glu289Asp), 4b/a, and T-786C) and the risk of DN published before July 2009, covering a total of 10,364 subjects. 20049477

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The meta-analysis showed that G894T is significantly associated with diabetic nephropathy and diabetes leading to severe nephropathy in type 2 diabetics and in East Asians, respectively. 19773668

2009

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE We evaluated the association of -786T>C (promoter region), Glu298Asp (Exon 7), and 4b4a (Intron 4) polymorphisms in eNOS gene with Type 2 diabetes mellitus (T2DM) and DN by haplotype analysis. 18413207

2008

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In contrast, the T allele is associated with increased oxidative stress in the renal circulation in patients with diabetes suggesting a specific role of the G894T polymorphism in the pathogenesis of diabetic nephropathy. 18622262

2008

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The Glu/Glu-genotype of the NOS3 Glu298Asp polymorphism may increase the risk of developing DN independently of other known risk factors. 17101543

2006

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Relations between eNOS Glu298Asp polymorphism and progression of diabetic nephropathy. 15331206

2004