Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.
After stratification by ethnicity, we found that the rs2241766 T/G dominant model (GG+TG vs. TT: OR 1.52; 95% CI 1.12-2.07; P = 0.007), heterozygous model (TG vs. TT: OR 1.52; 95% CI 1.01-2.27; P = 0.04) and G vs. T allele (OR 1.50; 95% CI 1.07-2.10; P = 0.02) may be associated with DN risk in the Caucasian population.
To derive a more precise estimation of this association, we performed a meta-analysis to assess the association between four ADIPOQ polymorphisms [-11391G > A (rs17300539), -11377C > G (rs266729), +45T > G (rs2241766), and +276G > T (rs1501299)] and risk for DN.
ADIPOQ genetic polymorphisms rs2241766 (+45T>G), rs1063537, rs2241767 and rs2082940 were correlated with the progression of DN in Taiwanese male patients with T2D.
The present study aims to examine the association of tumor necrosis factor-α (TNF-α) g.-308 G > A and adiponectin (ADIPOQ) g. + 45 T > G gene polymorphisms in type 2 diabetes (T2D) and its microvascular complications diabetic retinopathy (DR) and diabetic nephropathy (DN).
These data suggest that the GG genotype at rs2241766 is implicated in the pathogenesis of risk for diabetic nephropathy defined as UACR greater than 30 mg/day in patients with T2DM.