|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the gender differences in the effect of ACE I/D and AGT M235T polymorphisms on the prognosis of diabetic nephropathy (DN).
|
18849600 |
2009 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the relationship of the ACE insertion/deletion (I/D) and AGT M235T</span> gene polymorphisms in Turkish patients with type 2 diabetes mellitus (DM) with and without diabetic nephropathy.
|
18413162 |
2008 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The impact of polymorphisms in the genes coding for angiotensinogen (M235T), ACE (ID), and angiotensin II type 1 receptor (A(1166)-->C) on decline in GFR and doubling of s-creatinine or development of ESRD in patients with type 1 diabetes and diabetic nephropathy (DN) was tested.
|
14569094 |
2003 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Conflicting results on the relationship between M235T polymorphism of angiotensinogen (AGT) gene and diabetic nephropathy are reported in the literature, probably due to the small number of subjects, to different inclusion criteria and the different genotype analysis methods used.
|
12270765 |
2002 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A substitution (M235T) polymorphism in angiotensinogen (AGT) may interact with ACE I/D polymorphism for the risk of diabetic nephropathy, but their prognostic values have to be established by follow-up studies.
|
11181802 |
2001 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese.
|
11776100 |
2000 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we investigated the interaction between long-term glycaemic control and three polymorphisms in the genes coding for AGTR1 (A1166-->C), angiotensin converting enzyme (ACE/ID) and angiotensinogen (M235T) on risk of developing diabetic nephropathy.
|
10907125 |
2000 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The data do not support a role of ACE (DD/II) or Atg M235T polymorphism in the development of diabetic nephropathy in Chinese patients with type II diabetes, and no synergistic effect was found between them.
|
10352194 |
1999 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
9049480 |
1997 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggested that ACE I/D polymorphism, but not AGN M235T polymorphism, is a possible genetic risk factor for diabetic nephropathy in Japanese NIDDM patients.
|
8596493 |
1996 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy.
|
8877296 |
1996 |
|
rs1799752
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Minor allele frequency of rs1800764 was higher in DN patients than DWN patients or healthy controls, and minor allele frequency of rs1799752 was higher in DN than DWN patients.
|
19787680 |
2009 |
|
rs1799752
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the case-control analysis, the rs1800764-C, rs4311-T, Insertion/deletion (I/D or rs1799752)-D, rs4366-G, and rs12449782-G alleles were associated with an increased risk for DN, homogeneously across populations, with allelic odds ratios of 1.11 (95% confidence interval 1.00 to 1.22), 1.18 (1.04 to 1.33), 1.13 (1.02 to 1.23), 1.10 (0.99 to 1.20), and 1.12 (1.01 to 1.23), respectively.
|
17376814 |
2007 |
|
rs1341633213
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, a case-control study was carried out to investigate the effects of 7 SNPs in ACE gene and 2 SNPs in eNOS gene in the development of DN in Northern China.7 SNPs including A240T, A2350G, A5466C, A2215G, T3892C, C1237T and C3409T of ACE gene and 2 SNPs (G894T and T786C) of eNOS gene were genotyped by polymerase chain reaction restriction fragment length polymorphism method.
|
25227524 |
2015 |
|
rs4311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the case-control analysis, the rs1800764-C, rs4311-T, Insertion/deletion (I/D or rs1799752)-D, rs4366-G, and rs12449782-G alleles were associated with an increased risk for DN, homogeneously across populations, with allelic odds ratios of 1.11 (95% confidence interval 1.00 to 1.22), 1.18 (1.04 to 1.33), 1.13 (1.02 to 1.23), 1.10 (0.99 to 1.20), and 1.12 (1.01 to 1.23), respectively.
|
17376814 |
2007 |
|
rs4366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis further demonstrated that the haplotype defined by the D, rs4366_G and rs12449782_G alleles was associated with a greater risk for DN.
|
17376814 |
2007 |
|
rs1157043147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that TGF-beta T869C (Leu 10Pro) gene polymorphism is associated with DMN in Chinese.
|
12675860 |
2003 |