|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study showed that AGT M235T homozygous mutation significantly increase DN risk in Caucasian DM population and type 1 diabetes patients.
|
29775675 |
2018 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
AGT rs699 and rs4762 missense polymorphisms are not associated with DN in our subset of Slovenian T2DM patients.
|
28488548 |
2017 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A number of studies have evaluated the association between the functional polymorphisms, AGT M235T and AGTR1 A1166C, and DN risk with conflicting results.
|
21607620 |
2012 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study has shown that AGT M235T TT genotype and APO E ε 2/3 genotype may be linked to a risk for DN among Turkish population.
|
21500980 |
2011 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three-locus AGT haplotype analysis (A-6G/T174M/M235T) identified DN-protective (ATM, AMM, GTM) and DN-susceptible (GTM, ATT, GMT and AMT) haplotypes, and demonstrated enrichment of GTT haplotype in macroalbuminuric compared to microalbuminuric or normoalbuminuric patients.
|
21421655 |
2011 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the gender differences in the effect of ACE I/D and AGT M235T polymorphisms on the prognosis of diabetic nephropathy (DN).
|
18849600 |
2009 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the relationship of the ACE insertion/deletion (I/D) and AGT M235T</span> gene polymorphisms in Turkish patients with type 2 diabetes mellitus (DM) with and without diabetic nephropathy.
|
18413162 |
2008 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The impact of polymorphisms in the genes coding for angiotensinogen (M235T), ACE (ID), and angiotensin II type 1 receptor (A(1166)-->C) on decline in GFR and doubling of s-creatinine or development of ESRD in patients with type 1 diabetes and diabetic nephropathy (DN) was tested.
|
14569094 |
2003 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Conflicting results on the relationship between M235T polymorphism of angiotensinogen (AGT) gene and diabetic nephropathy are reported in the literature, probably due to the small number of subjects, to different inclusion criteria and the different genotype analysis methods used.
|
12270765 |
2002 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A substitution (M235T) polymorphism in angiotensinogen (AGT) may interact with ACE I/D polymorphism for the risk of diabetic nephropathy, but their prognostic values have to be established by follow-up studies.
|
11181802 |
2001 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese.
|
11776100 |
2000 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we investigated the interaction between long-term glycaemic control and three polymorphisms in the genes coding for AGTR1 (A1166-->C), angiotensin converting enzyme (ACE/ID) and angiotensinogen (M235T) on risk of developing diabetic nephropathy.
|
10907125 |
2000 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
AGT gene M235T polymorphism is associated with diabetic nephropathy in NIDDM.
|
11717948 |
1999 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The data do not support a role of ACE (DD/II) or Atg M235T polymorphism in the development of diabetic nephropathy in Chinese patients with type II diabetes, and no synergistic effect was found between them.
|
10352194 |
1999 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, results obtained in our family-based study support a role of the angiotensinogen gene M235T polymorphism, and specifically the T allele, in the development of diabetic nephropathy in IDDM.
|
9461232 |
1998 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DNA polymorphism M235T in the angiotensinogen gene, which is associated with higher expression of this gene, contributes to the risk of diabetic nephropathy in NIDDM men but not in women.
|
9535411 |
1998 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
9049480 |
1997 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that neither the M235T nor the T174M polymorphism in the angiotensinogen gene contributes to genetic susceptibility to diabetic nephropathy in white IDDM patients, whereas the TT genotype of the M235T is associated with elevated blood pressure in patients with diabetic nephropathy.
|
8593944 |
1996 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy.
|
8877296 |
1996 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The data argue against a role of the angiotensinogen gene M235T polymorphism in the manifestation of diabetic nephropathy or hypertension in diabetic patients.
|
8918618 |
1996 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggested that ACE I/D polymorphism, but not AGN M235T polymorphism, is a possible genetic risk factor for diabetic nephropathy in Japanese NIDDM patients.
|
8596493 |
1996 |
|
rs4762
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our study indicated that the T174M polymorphism in the AGT gene was associated with DN in Asians.
|
30798724 |
2019 |
|
rs4762
|
|
|
0.050 |
GeneticVariation |
BEFREE |
AGT rs699 and rs4762 missense polymorphisms are not associated with DN in our subset of Slovenian T2DM patients.
|
28488548 |
2017 |
|
rs4762
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Three-locus AGT haplotype analysis (A-6G/T174M/M235T) identified DN-protective (ATM, AMM, GTM) and DN-susceptible (GTM, ATT, GMT and AMT) haplotypes, and demonstrated enrichment of GTT haplotype in macroalbuminuric compared to microalbuminuric or normoalbuminuric patients.
|
21421655 |
2011 |
|
rs4762
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese.
|
11776100 |
2000 |